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Diabetologia

, Volume 23, Issue 1, pp 24–27 | Cite as

The effect of intensive dietary therapy on serum high density lipoprotein cholesterol in patients with type 2 (non-insulin-dependent) diabetes mellitus: A prospective study

  • L. Kennedy
  • K. Walshe
  • D. R. Hadden
  • J. A. Weaver
  • K. D. Buchanan
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Summary

Intensive dietary therapy in 57 newly diagnosed Type 2 (non-insulin-dependent) diabetic patients led to an increase, compared with pre-treatment levels, in serum high density lipoprotein (HDL) cholesterol and the HDL/total cholesterol ratio after 3 and 6 months (0.05<p<0.1). The increase in HDL cholesterol was related to the degree of weight loss achieved. In 28 patients whose weight decreased by ⩾ 10% average body weight during the 6 months, HDL cholesterol rose from 1.22±0.06 to 1.36±0.06 mmol/1 (p<0.001), whereas patients who lost less weight showed no significant increase in HDL cholesterol. The increase in mean serum HDL-cholesterol levels in female patients was associated with a mean weight reduction of 12.1% average body weight. Patients who were obese at diagnosis lost more weight during the study than non-obese patients (mean 13.2 versus 5.6% average body weight), and showed a significant increase in serum HDL-cholesterol levels. We conclude that intensive dietary therapy may lead to a less atherogenic lipid profile in Type 2 diabetes, particularly in patients who achieve a major weight reduction.

Key words

HDL-cholesterol triglyceride glucose tolerance dietary therapy weight loss Type 2 diabetes 

References

  1. 1.
    Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR (1977) High density lipoprotein as a protective factor against coronary heart disease. Am J Med 62: 707–714CrossRefPubMedGoogle Scholar
  2. 2.
    Miller GJ, Miller NE (1975) Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet 1: 16–19CrossRefPubMedGoogle Scholar
  3. 3.
    Kennedy AL, Lappin TRJ, Lavery TD, Hadden DR, Weaver JA, Montgomery DAD (1978) Relation of high density lipoprotein cholesterol concentration to type of diabetes and its control. Br Med J 2:1191–1194Google Scholar
  4. 4.
    Nikkila EA (1978) Metabolic and endocrine control of plasma high density lipoprotein concentration. In: Gotto AM, Miller NE, Oliver MF (eds) High density lipoproteins, Elsevier-North Holland, Amsterdam, pp 177–192Google Scholar
  5. 5.
    Taylor KG, Wright AD, Carter TJN, Valente AJ, Betts SA, Matthews KA (1981), High density lipoprotein cholesterol and apolipoprotein A-1 levels at diagnosis in patients with non-insulin dependent diabetes. Diabetologia 20: 535–539Google Scholar
  6. 6.
    Hadden DR, Wilson EA (1981) Dietary management of diabetes mellitus. Proc Nutr Soc 40: 247–255Google Scholar
  7. 7.
    Society of Actuaries, Build and Blood Pressure Study, vol I (1959) Society of Actuaries, Chicago, p 16Google Scholar
  8. 8.
    Hadden DR, Montgomery DAD, Skelly RJ, Trimble ER, Weaver JA, Wilson EA, Buchanan KD (1975) Maturity onset diabetes mellitus: response to intensive dietary management. Br Med J 2: 276–278PubMedGoogle Scholar
  9. 9.
    Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR (1977) Diabetes, blood lipids and the role of obesity in coronary heart disease risk for women: the Framingham study. Ann Intern Med 87:393–397Google Scholar
  10. 10.
    Reckless JPD, Betteridge DJ, Wu P, Payne B, Galton DJ (1978) High density and low density lipoproteins and prevalence of vascular disease in diabetes mellitus. Br Med J 1: 883–886Google Scholar
  11. 11.
    Witzum J, Schonfeld G (1979) High density lipoproteins. Diabetes 28:326–333Google Scholar
  12. 12.
    Streja DA, Boyko E, Rabkin SW (1980) Changes in plasma high density lipoprotein cholesterol concentration after weight reduction in grossly obese subjects. Br Med J 2: 770–772Google Scholar
  13. 13.
    Yudkin J, Kang SS, Bruckdorfer KR(1980) Effects of high dietary sugar. Br Med J 2:1396Google Scholar
  14. 14.
    Reaven GM (1980) How high the carbohydrate? Diabetologia 19: 409–413Google Scholar
  15. 15.
    Taylor KG, Galton DJ, Holdsworth G (1979) Insulin-dependent diabetes: a defect in the activity of lipoprotein lipase in adipose tissue. Diabetologia 16: 313–317Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • L. Kennedy
    • 1
  • K. Walshe
    • 1
  • D. R. Hadden
    • 1
  • J. A. Weaver
    • 1
  • K. D. Buchanan
    • 2
  1. 1.Diabetes ClinicRoyal Victoria HospitalBelfastUK
  2. 2.Queen's University of BelfastBelfastUK

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