, Volume 23, Issue 1, pp 24–27 | Cite as

The effect of intensive dietary therapy on serum high density lipoprotein cholesterol in patients with type 2 (non-insulin-dependent) diabetes mellitus: A prospective study

  • L. Kennedy
  • K. Walshe
  • D. R. Hadden
  • J. A. Weaver
  • K. D. Buchanan


Intensive dietary therapy in 57 newly diagnosed Type 2 (non-insulin-dependent) diabetic patients led to an increase, compared with pre-treatment levels, in serum high density lipoprotein (HDL) cholesterol and the HDL/total cholesterol ratio after 3 and 6 months (0.05<p<0.1). The increase in HDL cholesterol was related to the degree of weight loss achieved. In 28 patients whose weight decreased by ⩾ 10% average body weight during the 6 months, HDL cholesterol rose from 1.22±0.06 to 1.36±0.06 mmol/1 (p<0.001), whereas patients who lost less weight showed no significant increase in HDL cholesterol. The increase in mean serum HDL-cholesterol levels in female patients was associated with a mean weight reduction of 12.1% average body weight. Patients who were obese at diagnosis lost more weight during the study than non-obese patients (mean 13.2 versus 5.6% average body weight), and showed a significant increase in serum HDL-cholesterol levels. We conclude that intensive dietary therapy may lead to a less atherogenic lipid profile in Type 2 diabetes, particularly in patients who achieve a major weight reduction.

Key words

HDL-cholesterol triglyceride glucose tolerance dietary therapy weight loss Type 2 diabetes 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • L. Kennedy
    • 1
  • K. Walshe
    • 1
  • D. R. Hadden
    • 1
  • J. A. Weaver
    • 1
  • K. D. Buchanan
    • 2
  1. 1.Diabetes ClinicRoyal Victoria HospitalBelfastUK
  2. 2.Queen's University of BelfastBelfastUK

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