European Journal of Pediatrics

, Volume 158, Supplement 3, pp S126–S129 | Cite as

Coagulation-associated complications of indwelling arterial and central venous catheters during heparin prophylaxis – a prospective study

  • R. Hentschel
  • U. Wiescholek
  • J. von Lengerke
  • E. Harms
  • G. Jorch
THROMBOPHILIA

Abstract

A prospective observational study was carried out to investigate complications of arterial and venous indwelling catheters. All patients of a mixed NICU/PICU admitted during a 12-month period were enrolled in this study with a stringent protocol of catheter prophylaxis, using heparin via continuous infusion in a dose of 100 IU/kg/day body weight or at least 100 IU/kg/day for each arterial and/or central venous catheter. Patients were regularly monitored for edema, thrombus, ischemia and catheter obstruction, i.e. complications amenable to heparinization. A total of 292 catheters in 130 patients were recorded. Patients' weight ranged between approximately 600 g to 10,000 g. Depending on the insertion site or type of catheter the frequency of complications was as follows: edema 0–12%; catheter obstruction 7–24%; ischemia 28–40%. No case of persistent thrombosis was detected.

Conclusion A stringent protocol of heparinization leads to a low incidence of complications potentially amenable to anticoagulation.

Key words Thrombosis Embolism Heparin Central venous catheterization Arterial catheterization 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. Hentschel
    • 1
  • U. Wiescholek
    • 2
  • J. von Lengerke
    • 2
  • E. Harms
    • 2
  • G. Jorch
    • 2
  1. 1.Intensive Care Unit, Department of Pediatrics, University of Freiburg, GermanyDE
  2. 2.Department of Pediatrics, University of Münster, GermanyDE

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