DAX-1, an ‘antitestis’gene

  • P. N. Goodfellow
  • G. Camerino


The DAX-1 gene has been involved in the dosage sensitive sex reversal (DSS) phenotype, a male-to-female sex-reversal syndrome due to the duplication of a small region of human chromosome Xp21. Dax-1 and Sry have been shown to act antagonistically in the mouse system, where increasing expression of the former leads to female development and increasing activity of the latter to male development. Although these data strongly implicate DAX-1 in sex determination, the mouse and human proteins appear to behave differently. Absence of DAX-1 is responsible for adrenal hypoplasia congenita, a human inherited disorder characterized by adrenal insufficiency and hypogonadotropic hypogonadism. Unlike human patients, Dax-1-deficient XY mice have normal levels of corticotropins and adrenal hormones but are sterile. Dax-1-deficient females are fertile. The DAX-1 protein, an unusual member of the nuclear hormone receptor, may act as a transcriptional repressor. It has been shown to both repress transcriptional activators by direct protein-protein interactions and to bind DNA hairpin structures and repress target genes.

Key words.DAX-1; AHC; sex determination; male-to-female sex reversal; adrenal development. 


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Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • P. N. Goodfellow
    • 1
  • G. Camerino
    • 2
  1. 1.Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH (UK)UK
  2. 2.Biologia Generale e Genetica Medica, Universitá di Pavia, via Forlanini 14, I-27100 Pavia (Italy), Fax +39 382 525030, e-mail: camerino@unipv.itIT

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