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World Journal of Surgery

, Volume 23, Issue 2, pp 177–181 | Cite as

Clinically Significant, Isolated Metastatic Disease to the Thyroid Gland

  • Herbert Chen
  • Theresa L. Nicol
  • Robert Udelsman

n

= 5), esophageal adenocarcinoma (n= 1), pulmonary squamous cell carcinoma (n= 1), gastric leiomyosarcoma (n= 1), lingual squamous cell carcinoma (n= 1), and parotid gland carcinoma (n= 1). Three patients underwent preoperative fine-needle aspiration (FNA), all of which were suggestive of metastatic disease. The mean time from resection of the primary tumor to thyroid metastases was 3.5 ± 6.0 years (range 0–19.5 years). Total thyroidectomy (n= 5) or lobectomy (n= 5) was performed without morbidity or mortality. After a median follow-up of 5.2 years six patients are alive and two are free of disease. Moreover, no patients have had recurrent disease in the neck. Thus carcinomas metastatic to the thyroid represent a rare cause of clinically significant thyroid disease, with RCCs comprising 50%. Most thyroid metastases (80%) present within 3 years of primary tumor resection, but with RCC they can occur as late as 19 years. The diagnosis of metastatic disease should be suspected in patients with even a remote history of cancer, especially RCC, and an FNA revealing clear cell or spindle cell carcinoma. Contrary to previous reports, long-term survival can be achieved after resection of the metastatic tumor. Furthermore, thyroidectomy may also palliate/prevent the potential morbidity of tumor recurrence in the neck.

Keywords

Squamous Cell Carcinoma Metastatic Disease Thyroid Gland Spindle Cell Parotid Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Société Internationale de Chirugie 1999

Authors and Affiliations

  • Herbert Chen
    • 1
  • Theresa L. Nicol
    • 2
  • Robert Udelsman
    • 1
  1. 1.Division of Endocrine and Oncologic Surgery, Department of Surgery, Blalock 688, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, Maryland 21287, USAUS
  2. 2.Department of Pathology, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, Maryland 21287, USA and The Johns Hopkins Thyroid Tumor Center, 600 North Wolfe Street, Baltimore, Maryland 21287, USAUS

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