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Cellular and Molecular Life Sciences CMLS

, Volume 59, Issue 11, pp 1902–1913 | Cite as

Bacterial cold-shock proteins

  • D. N. Ermolenko
  • G. I. Makhatadze

Abstract.

Members of a family of small cold-shock proteins (CSPs) are induced during bacterial cell response to a temperature decrease. Here we review available data about the structure, molecular properties, mechanism of induction and possible functions of CSPs. CSPs preferentially bind single-stranded RNA and DNA and appear to play an important role in cell physiology under both normal and cold-shock conditions. Although the function of CSPs in cold-shock adaptation has not yet been elucidated in detail, a number of experimental evidences suggests that CSPs bind messenger RNA (mRNA) and regulate ribosomal translation, rate of mRNA degradation and termination of transcription.

Key words. ssDNA/RNA binding protein; RNA chaperone; regulation of transcription; regulation of translation; bacterial cold shock; cold adaptation. 

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Copyright information

© Birkhäuser Verlag, 2002

Authors and Affiliations

  • D. N. Ermolenko
    • 1
  • G. I. Makhatadze
    • 1
  1. 1.Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, Pennsylvania 17033 (USA), Fax: +1 717 531 7072, e-mail: makhatadze@psu.eduUS

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