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Human Genetics

, Volume 100, Issue 2, pp 151–154 | Cite as

Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23

  • S. Taviaux
  • M. E. Williams
  • M. M. Harpold
  • J. Nargeot
  • P. Lory
Original investigation

Abstract

We have used human β2 and β4 cDNA probes to map the genes encoding two isoforms of the regulatory β subunit of voltage-activated Ca2+ channels, viz. CACNB2 (β2) and CACNB4 (β4), to human chromosomes 10p12 and 2q22-q23, respectively, by fluorescence in situ hybridization. The gene encoding the β2 protein, first described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS. CACNB2 (β2) and CACNB4 (β4) genes are members of the ion-channel gene superfamily and it should now be possible to examine their loci by linkage analysis of ion-channel-related disorders. To date, no such disease-related gene has been assigned to 10p12 and 2q22-q23.

Keywords

Lung Cancer Cell Lung Cancer Linkage Analysis Small Cell Lung Cancer Human Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. Taviaux
    • 1
  • M. E. Williams
    • 2
  • M. M. Harpold
    • 2
  • J. Nargeot
    • 1
  • P. Lory
    • 1
  1. 1.CRBM–CNRS, BP 5051–1919, Route de Mende, F-34033 Montpellier cedex, France Tel.: +33-4-67-613355; Fax: +33-4-67-521559; e-mail: lory@xerxes.crbm.cnrs-mop.frFR
  2. 2.SIBIA Neurosciences, Inc., 505 Coast Boulevard South, Suite 300, La Jolla, California 92037–4641, USAUS

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