Parasitology Research

, Volume 87, Issue 4, pp 294–298

Eprinomectin in dairy goats: dose influence on plasma levels and excretion in milk

  • J. Dupuy
  • C. Chartier
  • J. F. Sutra
  • M. Alvinerie
ORIGINAL PAPER

Abstract

The plasma levels and milk excretion of eprinomectin were determined in goats following topical application at doses of 0.5 mg kg−1 and 1.0 mg kg−1. The area under the concentration–time curve (AUC) was 2 times lower for 0.5 mg kg−1 (8.24 ± 3.50 ng day−1 ml−1) than for 1.0 mg kg−1 (15.68 ± 8.84 ng day−1 ml−1), suggesting that the pharmacokinetics of eprinomectin in goats is dose independent. The bioavailability of eprinomectin in lactating compared with non-lactating goats is low. This is probably due to the physiological status of dairy animals, which present a marked decrease in body fat. Comparison of the eprinomectin concentrations in the milk and plasma demonstrated a parallel disposition of the drug with a milk-to-plasma ratio of 0.10–0.25. The amount of drug recovered in the milk was 0.3–0.5% of the total administered dose. In all cases, the maximum level of residue in milk remained below the maximum acceptable level of 30 ng ml−1 permitted in lactating cattle.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • J. Dupuy
    • 1
  • C. Chartier
    • 2
  • J. F. Sutra
    • 1
  • M. Alvinerie
    • 1
  1. 1.INRA-Toulouse, Laboratoire de Pharmacologie-Toxicologie, 180 Chemin de Tournefeuille, B.P. 3, 31931 Toulouse Cedex 9, France e-mail: malviner@toulouse.inra.fr Fax: +33-5-61285310FR
  2. 2.AFFSA, Laboratoire de Recherches Caprines, 60 Rue de Pied de Fond, 79012 Niort, FranceFR

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