European Journal of Pediatrics

, Volume 160, Issue 6, pp 333–338 | Cite as

High birth weight and other risk factors for Wilms tumour: results of a population-based case-control study

  • Joachim Schüz
  • Uwe Kaletsch
  • Rolf Meinert
  • Peter Kaatsch
  • Jörg Michaelis
ORIGINAL PAPER

Abstract

Wilms tumour, or nephroblastoma, is one of the childhood cancers included in two recent population-based case-control studies in West Germany. Altogether, 177 children under the age of 10 years with Wilms tumour diagnosed between 1988 and 1994 and 2006 control children sampled from population registration files participated. Information on potential risk factors was obtained from the parents using a questionnaire and by subsequent telephone interview. We found an association with a high birth weight >4000 g (odds ratio 1.58; 95% confidence interval 1.01–2.48), which was somewhat stronger for children aged 2 years or older. Findings for young maternal age at birth and certain parental occupationally related exposures were not reported by previous studies and thus may be chance findings. As opposed to previous studies, we failed to confirm associations with high parental age at birth, maternal coffee and tea consumption during pregnancy, and exposure to pesticides.

Conclusion Based on this large population-based case-control study, high birth weight may play a role in the aetiology of Wilms tumour, but many risk factors previously suggested are of less importance.

Key words Case-control study Child Nephroblastoma Risk factors Wilms tumour 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Joachim Schüz
    • 1
  • Uwe Kaletsch
    • 1
  • Rolf Meinert
    • 1
  • Peter Kaatsch
    • 1
  • Jörg Michaelis
    • 1
  1. 1.Institut für Medizinische Statistik und Dokumentation, Johannes Gutenberg-Universität Mainz, 55101 Mainz, Germany Tel.: +49-6131-173113; Fax: +49-6131-172968 e-mail: schuez@imsd.uni-mainz.deDE

Personalised recommendations