European Journal of Pediatrics

, Volume 159, Issue 12, pp 898–900

Early infantile pertussis; increasingly prevalent and potentially fatal

  • Craig Smith
  • Harish Vyas

DOI: 10.1007/PL00008365

Cite this article as:
Smith, C. & Vyas, H. Eur J Pediatr (2000) 159: 898. doi:10.1007/PL00008365


We report nine cases of severe early pertussis in infants less than 7 weeks of age. Clinical features at this age are atypical and may be confused with more common illnesses such as bronchiolitis. All were very difficult to manage. Ventilation was required for apnoeas in five cases, seizures in two or respiratory failure in two. Complications included hypotension in seven cases, pulmonary hypertension in one, pneumothoraces in two, seizures in five and co-infection in five. Two cases were referred for extracorporeal membrane oxygenation and six died. Infection was confirmed either at post mortem or by culture from pernasal swabs. The mother or other close family members were symptomatic at the time and thought to be the source of infection.

Conclusion The nine cases suggest a significant resurgence of the infection, which may be fatal in early life. If reporting continues to increase, the immunisation schedule will need to be reviewed and secondary transmission prevented where possible, to protect this vulnerable pre-immunisation group.

Key words Immunisation Infantile Pertussis Vaccination 
AbbreviationsECMO extracorporeal membrane oxygenation HFOV high frequency oscillatory ventilation RSV respiratory syncytial virus 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Craig Smith
    • 1
  • Harish Vyas
    • 1
  1. 1.Paediatric Intensive Care Unit, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK e-mail: Tel.: +44-115-9249924 extension 44841; Fax: 44-115-9420324GB

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