Journal of Neurology

, Volume 244, Issue 1, pp 9–16 | Cite as

Drug therapy for acquired pendular nystagmus in multiple sclerosis

  • M. Starck
  • H. Albrecht
  • W. Pöllmann
  • A. Straube
  • M. Dieterich
Original communication

Abstract

Acquired pendular nystagmus (APN) is regularly accompanied by oscillopsia and impairment of static visual acuity. Therapeutic approaches to APN remain controversial, and there is no generally accepted therapeutic approach. We tested 14 patients who had suffered from APN caused by multiple sclerosis for several years; 12 patients presented with fixational pendular nystagmus (increasing during fixation) and 2 with spontaneous pendular nystagmus. All 11 patients with fixational pendular nystagmus who were given memantine, a glutamate antagonist, experienced complete cessation of the nystagmus. In contrast, scopolamine caused no (6 of 8) or only a minor (10–50%) reduction of the nystagmus (2 of 8). It was concluded that memantine is a safe treatment option for APN.

Key words Acquired nystagmus Multiple sclerosis Drug therapy Memantine Scopolamine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. Starck
    • 2
  • H. Albrecht
    • 2
  • W. Pöllmann
    • 2
  • A. Straube
    • 1
  • M. Dieterich
    • 1
  1. 1.Department of Neurology, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, D-81377 Munich, Germany Tel.: 0049 89 70953678, Fax: 0049 89 7095 8883DE
  2. 2.Marianne-Strauss-Klinik, D-82335 Berg-Kempfenhausen, Germany Tel.: 0049 8151 261922, Fax: 0049 8151 261923DE

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