White blood cells and cortisol after sleep deprivation and recovery sleep in humans

  • P. Heiser
  • B. Dickhaus
  • W. Schreiber
  • H. W. Clement
  • C. Hasse
  • J. Hennig
  • H. Remschmidt
  • J. C. Krieg
  • W. Wesemann
  • C. Opper
Original paper

DOI: 10.1007/PL00007534

Cite this article as:
Heiser, P., Dickhaus, B., Schreiber, W. et al. European Archives of Psychiatry and Clinical Neurosciences (2000) 250: 16. doi:10.1007/PL00007534

Abstract

Sleep deprivation (SD) has enriched our treatment programme for major depression. SD has been demonstrated to modify different host defence activities. There is some evidence that there are reciprocal relationships between immune function and increased hypothalamic-pituitary-adrenocortical (HPA) axis activity in depression. We therefore investigated the number of leukocytes, granulocytes, monocytes, lymphocytes, B cells, ¶T cells, helper T cells, cytotoxic T cells, NK cells and salivary cortisol in 10 healthy men before and after total SD (TSD) as well as after recovery sleep. Blood samples were drawn on 3 consecutive days at 7 am, 1 pm and ¶7 pm, respectively. Comparison of the 7 am values by contrast analysis yielded significant differences for granulocytes (p = 0.044) and NK cells (p = 0.001) after SD and recovery sleep. NK cells decreased and granulocytes increased after SD and after recovery sleep. Significant differences between single points in time across the day were found for granulocytes (p = 0.022), monocytes (p = 0.031), T cells (p = 0.005), helper T cells (p = 0.004), cytotoxic T cells (p = 0.005) and NK cells (p = 0.017). No significant difference could be detected for leukocytes, lymphocytes and B cells counts. These results favour the thesis that SD and recovery sleep lead to changes in the distribution of peripheral leukocytes, especially in a reduction of NK cells after SD and recovery sleep. The cortisol rhythm was affected neither by SD nor recovery sleep.

Key words Leukocyte Subpopulation Cortisol Sleep deprivation Depression 

Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • P. Heiser
    • 1
  • B. Dickhaus
    • 2
  • W. Schreiber
    • 3
  • H. W. Clement
    • 2
  • C. Hasse
    • 2
  • J. Hennig
    • 4
  • H. Remschmidt
    • 1
  • J. C. Krieg
    • 3
  • W. Wesemann
    • 2
  • C. Opper
    • 2
  1. 1.Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Hans-Sachs-Str. 6, 35039 Marburg, Germany, e-mail: heiser@mailer.uni-marburg.deDE
  2. 2.Department of Neurochemistry, University of Marburg, Hans-Meerwein-Str, 35043 MarburgDE
  3. 3.Department of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Str. 8, 35043 MarburgDE
  4. 4.Department of Psychology, University of Giessen, Otto-Behaghel-Str. 10, 35394 GiessenDE

Personalised recommendations