Journal of Molecular Evolution

, Volume 47, Issue 1, pp 109–117 | Cite as

Amino Acids as RNA Ligands: A Direct-RNA-Template Theory for the Code's Origin

  • Michael  Yarus


Numerous RNA binding sites for specific amino acids are now known, coming predominantly from selection-amplification experiments. These sites are chemically discriminating despite being predominantly small, simple RNA structures: internal and bulge loops. Recent studies of sites for hydrophobic side chains suggest that there are other generalizable structural features which recur in hydrophobic RNA sites. Further, sites for hydrophobic side chains can contain codons for the bound amino acid, as has also long been known for the polar amino acid arginine. Such findings are comprehensively reviewed, and the implications for the origin of coded peptide synthesis are considered. An origins hypothesis which accommodates all the data, DRT (direct RNA templating), is formulated.

Key words: Selection-amplification — Genetic code — Affinity selection — RNA structure — Internal loop 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag New York Inc. 1998

Authors and Affiliations

  • Michael  Yarus
    • 1
  1. 1.Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USAUS

Personalised recommendations