Experimental Brain Research

, Volume 115, Issue 1, pp 1–5 | Cite as

Differential roles of monkey striatum in learning of sequential hand movement

  • S. Miyachi
  • O. Hikosaka
  • K. Miyashita
  • Z. Kárádi
  • M. K. Rand
RESEARCH ARTICLE

Abstract

 To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2×5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the anterior caudate and putamen, but not the middle-posterior putamen. The execution of well-learned sequences was disrupted after injections in the middle-posterior putamen and, less severely, after injections in the anterior caudate/putamen. These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements.

Key words Procedural learning Basal ganglia Caudate Putamen Muscimol Monkey 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. Miyachi
    • 1
  • O. Hikosaka
    • 1
  • K. Miyashita
    • 1
  • Z. Kárádi
    • 1
  • M. K. Rand
    • 1
  1. 1.Laboratory of Neural Control, National Institute for Physiological Sciences, Okazaki 444, JapanJP

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