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Experimental Brain Research

, Volume 113, Issue 3, pp 509–519 | Cite as

Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix

  • A. Ennaceur
  • Nick Neave
  • John P. Aggleton
RESEARCH ARTICLE

Abstract

 The first experiment assessed the effects of neurotoxic lesions in either the anterior cingulate cortex (ACc) or the retrosplenial cortex (RSc) on a test of object recognition. Neither lesion affected performance on this task, which takes advantage of the rat’s normal preference to spend more time investigating novel rather than familiar stimuli. In response to this negative result, a second experiment assessed the effects of much more extensive cingulate lesions (Cg) on both object recognition and object location memory. The latter task also used a preference measure, but in this case it concerned preference for a novel location. For comparison purposes this second study included groups of rats with lesions in closely allied regions: the fornix (Fx), the cingulum bundle (CB) and the medial prefrontal cortex (Pfc). Comparisons with sham-operated control rats showed that none of the four groups (Cg, Fx, CB, Pfc) was impaired on the object recognition task, adding further weight to the view that these structures are not necessary for assessing stimulus familiarity. The Fx and Cg groups were, however, impaired on the object location task, suggesting that these regions are necessary for remembering other attributes of a stimulus (spatial location).

Key words Fornix Cingulate cortex Prefrontal cortex Cingulum bundle Hippocampus Object recognition Object location Memory Rat 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Ennaceur
    • 1
  • Nick Neave
    • 1
  • John P. Aggleton
    • 2
  1. 1.University of Durham, Department of Psychology, South Road, Durham DH1 3LE, UK; Fax: +44 (191) 374 74 74, e-mail: abdelkader.ennaceur@durham.ac.ukGB
  2. 2.School of Psychology, University of Wales College of Cardiff, PO Box 901, Cardiff CF1 3YG, UKGB

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