Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 8, pp 1014–1020 | Cite as

Genes for neurotrophic factors and their receptors: structure and regulation

  • M. Metsis


Neurotrophins and their receptors have attracted much interest during the last two decades. Although the mode of action of molecules of the neurotrophin system has been studied extensively, information on molecular mechanisms governing their expression is mosaic and incomplete. This review attempts to summarize the data available on gene structure and transcriptional regulation of neurotrophins and their receptors, and outlines perspectives for the future in this field.

Key words: Neurotrophin; receptor; tyrosine kinase; gene regulation; transcription. 


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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • M. Metsis
    • 1
  1. 1.Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Berzelius vägen 7, 17177 Stockholm (Sweden)¶Laboratory of Molecular Genetics and Center for Gene Technology, National Institute of Chemical Physics and Biophysics and Tallinn Technical University, Akadeemia tee 23, 12618 Tallinn (Estonia)EE

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