Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 3, pp 434–441

Melanocortin receptors: their functions and regulation by physiological agonists and antagonists

  • Z.A. Abdel-Malek


The melanocortins are a family of bioactive peptides derived from proopiomelanocortin, and share significant structural similarity. Those peptides are best known for their stimulatory effects on pigmentation and steroidogenesis. Melanocortins are synthesized in various sites in the central nervous system and in peripheral tissues, and participate in regulating multiple physiological functions. Research during the past decade has provided evidence that melanocortins elicit their diverse biological effects by binding to a distinct family of G protein-coupled receptors with seven transmembrane domains. To date, five melanocortin receptor genes have been cloned and characterized. Those receptors differ in their tissue distribution and in their ability to recognize the various melanocortins and the physiological antagonists, agouti signaling protein and agouti-related protein. These advances have opened new horizons for exploring the significance of melanocortins, their antagonists, and their receptors in a variety of important physiological functions.

Key words: Melanocortin receptor; proopiomelanocortin, melanocortin; agouti signaling protein; agouti-related protein 


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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • Z.A. Abdel-Malek
    • 1
  1. 1.Department of Dermatology, University of Cincinnati, PO Box 670592, 231 Albert Sabin Way, Room 7409 Cincinnati, (Ohio 45267-0592, USA), Fax: +15135580198, e-mail: abdelmza@email.uc.eduUS

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