Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 2, pp 278–288 | Cite as

Molecular genetic analysis of the calcineurin signaling pathways

  • R. Sugiura
  • S. O. Sio
  • H. Shuntoh
  • T. Kuno*

Abstract.

Calcineurin is a Ca2+- and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the powerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T cell activation, muscle hypertrophy, memory development, glucan synthesis, ion homeostasis, and cell cycle control. Notably, specific transcription factors have been shown to play a key role in regulating these functions, and their calcineurin-mediated dephosphorylation and nuclear translocation appear to be a central event in the signal transduction pathways. This review focuses on recent progress in these areas and discusses the evidence for cross-talk between calcineurin and other signaling pathways.

Key words. Calcineurin; protein phosphatase; cross-talk; transcription factor; MAP kinase. 

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Copyright information

© Birkhäuser Verlag Basel, 2001

Authors and Affiliations

  • R. Sugiura
    • 1
  • S. O. Sio
    • 2
  • H. Shuntoh
    • 3
  • T. Kuno*
    • 1
  1. 1.Department of Pharmacology, Kobe University School of Medicine, Kobe 650-0017 (Japan), Fax +81 78 382 5459, e-mail: tkuno@kobe-u.ac.jp JP
  2. 2.Department of Pharmacology, College of Medicine, University of the Philippines Manila, Manila 1000 (Philippines) PH
  3. 3.Faculty of Health Science, Kobe University School of Medicine, Kobe 654-0142 (Japan) JP

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