Advertisement

Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 12–13, pp 1758–1765 | Cite as

Nuclear envelope and nuclear matrix: interactions and dynamics

  • S. Vlcek
  • T. Dechat
  • R. Foisner

Abstract:

The peripheral nuclear lamina is located near the nuclear inner membrane and consists of lamin filaments and integral membrane proteins, including the lamin B receptor and various isoforms of lamina-associated polypeptides (LAP) 1 and 2. Several nuclear membrane proteins also interact with chromatin proteins BAF and Hp1. Lamins in the nuclear interior associate with at least one soluble (non-membrane-bound) LAP2 isoform named LAP2α. The internal lamins, together with Tpr-based filaments that connect to nuclear pore complexes, are proposed to be major structural elements of the internal nuclear matrix. We describe the structural links between the peripheral lamina and the internal nuclear matrix that are thought to be mediated by LAP2 family members, filament protein Tpr and nucleoporin Nup153. These findings are discussed in relation to human diseases that arise from mutations in nuclear lamina proteins.

Key words: Barrier-to-autointegration factor; cell cycle; chromatin structure; heterochromatin protein 1; lamin B receptor; lamina-associated polypeptide; lamins; nuclear matrix; nuclear pore complex; Tpr; transcriptional regulation. 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • S. Vlcek
    • 1
  • T. Dechat
    • 1
  • R. Foisner
    • 1
  1. 1.Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohrgasse 9, 1030 Vienna (Austria), Fax + 43 1 4277 52854, e-mail: foisner@abc.univie.ac.at AT

Personalised recommendations