Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 8–9, pp 1207–1219

Regulation of transcription factors by protein degradation

  • J. M. P. Desterro
  • M. S. Rodriguez
  • R. T. Hay*

DOI: 10.1007/PL00000760

Cite this article as:
Desterro, J., Rodriguez, M. & Hay*, R. CMLS, Cell. Mol. Life Sci. (2000) 57: 1207. doi:10.1007/PL00000760

Abstract.

The level of transcription factors is tightly controlled by their rates of synthesis and degradation. Many critical factors are maintained at an appropriate level by targeted addition of ubiquitin and degradation via the proteasome. Whereas ubiquitination targets modified proteins for degradation, modification of substrates by the family of ubiquitin-like proteins does not target the proteins for degradation but can alter the stability and other properties of the modified proteins. Here we discuss the elaborate mechanisms that have evolved to allow specific recognition of substrates targeted for modification. Specific examples are discussed to illustrate the different mechanisms involved and the importance of regulated degradation in diseases such as cancer.

Key words. Transcription; protein degradation; ubiquitin; SUMO-1. 

Copyright information

© Birkhäuser Verlag Basel, 2000

Authors and Affiliations

  • J. M. P. Desterro
    • 1
  • M. S. Rodriguez
    • 1
  • R. T. Hay*
    • 1
  1. 1.School of Biology, BMS Building, University of St. Andrews, St. Andrews, Fife KY16 9ST (United Kingdom), Fax +44 1334 462595, e-mail: rth@st-and.ac.uk GB

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