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Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 4, pp 604–611 | Cite as

Ras-related and MAPK signalling in neuronal plasticity and memory formation

  • C. Mazzucchelli
  • R. Brambilla*

Abstract.

Ras-related guanosine triphosphatases (GTPases) couple receptor activity to a number of intracellular signalling events culminating in the control of cell morphology and gene transcription. In culture cells, the best-understood Ras-dependent signalling pathway involves the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK) cascade. A growing body of evidence has recently been accumulating to suggest a crucial role of Ras and MAPK signalling in neuronal functions connected to synaptic plasticity. In the present review article we discuss the experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes.

Key words. Ras/MAPK signalling; synaptic plasticity; learning and memory; hippocampus. 

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Copyright information

© Birkhäuser Verlag Basel, 2000

Authors and Affiliations

  • C. Mazzucchelli
    • 1
  • R. Brambilla*
    • 1
  1. 1.San Raffaele Scientific Institute, via Olgettina 58, I-20132 Milano (Italy), Fax +39 02 2643 4767, e-mail: r.brambilla@hsr.itIT

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