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Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 12, pp 1810–1816 | Cite as

Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome

  • S. H. Kim
  • R. Vlkolinsky
  • N. Cairns
  • G. Lubec*

Abstract.

Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD.

Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. 

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Copyright information

© Birkhäuser Verlag Basel, 2000

Authors and Affiliations

  • S. H. Kim
    • 1
  • R. Vlkolinsky
    • 1
  • N. Cairns
    • 2
  • G. Lubec*
    • 1
  1. 1.Department of Pediatrics, University of Vienna, Waehringer Guertel 18, A-1090 Vienna (Austria), Fax +43 1 40400 3194, e-mail: gert.lubec@akh-wien.ac.at AT
  2. 2.Institute of Psychiatry, Brain Bank, King’s College, London (U.K.)UK

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