Journal of Biosciences

, Volume 25, Issue 2, pp 197–209 | Cite as

Dynamical complexity and temporal plasticity in pancreatic gβb-cells

  • Richard Bertram
  • Arthur Sherman


We discuss some of the biological and mathematical issues involved in understanding and modelling the bursting electrical activity in pancreatic gβb-cells. These issues include single-cell versus islet behaviour, parameter heterogeneity, channel noise, the effects of hormones, neurotransmitters, and ions, and multiple slow biophysical processes. Some of the key experimental and modelling studies are described, and some of the major open questions are discussed.


Bursting coupled oscillators mathematical model 


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Copyright information

© Indian Academy of Sciences 2000

Authors and Affiliations

  1. 1.Institute of Molecular BiophysicsFlorida State UniversityTallahasseeUSA
  2. 2.Mathatical Research Branch, National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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