, Volume 15, Issue 1, pp 35–44 | Cite as

Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

  • Djuro MacutEmail author
  • Ivana Božić Antić
  • Jelica Bjekić-Macut
  • Dimitrios Panidis
  • Konstantinos Tziomalos
  • Danijela Vojnović Milutinović
  • Olivera Stanojlović
  • Biljana Kastratović-Kotlica
  • Milan Petakov
  • Nataša Milić
Research paper


OBJECTIVE: There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS. DESIGN: We studied 222 women with PCOS who were diagnosed using the Rotterdam criteria. In all the subjects and controls, LAP was determined and the MetS was assessed using three different international criteria, NCEP-ATP III, IDF, and JIS. ROC curve and logistic regression analyses were performed to determine and analyze associations with the MetS. RESULTS: In the study population the prevalence of MetS was 16.2–19.4%. The cut-off value of 25.9 determined that LAP has the strongest association with MetS whichever international criteria are used, followed by HDL (NCEP-ATP III and JIS) and glucose (IDF). CONCLUSIONS: LAP is used as an independent clinical indicator for MetS in our PCOS women of Caucasian origin. The high diagnostic accuracy of LAP is superseding the need for the use of multiple clinical indicators for the assessment of lipid accumulation as a prerequisite for diagnosis of metabolic and cardiovascular diseases in PCOS women.

Key words

Lipid accumulation product Metabolic syndrome Polycystic ovary syndrome Triglycerides Waist circumference 


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Copyright information

© Hellenic Endocrine Society 2016

Authors and Affiliations

  • Djuro Macut
    • 1
    Email author
  • Ivana Božić Antić
    • 1
  • Jelica Bjekić-Macut
    • 2
  • Dimitrios Panidis
    • 3
  • Konstantinos Tziomalos
    • 4
  • Danijela Vojnović Milutinović
    • 5
  • Olivera Stanojlović
    • 6
  • Biljana Kastratović-Kotlica
    • 7
  • Milan Petakov
    • 1
  • Nataša Milić
    • 8
  1. 1.Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Faculty of MedicineUniversity of BelgradeBelgradeSerbia
  2. 2.CHC Bežanijska kosaBelgradeSerbia
  3. 3.Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and GynecologyAristotle University of Thessaloniki, Hippokration HospitalThessalonikiGreece
  4. 4.First Propedeutic Department of Internal MedicineAristotle University of Thessaloniki, AHEPA HospitalThessalonikiGreece
  5. 5.Department of Biochemistry, Institute for Biological Research “Siniša Stanković”University of BelgradeBelgradeSerbia
  6. 6.Institute of Medical Physiology, Faculty of MedicineUniversity of BelgradeBelgradeSerbia
  7. 7.Clinic for Obstetrics and Gynecology, Faculty of MedicineUniversity of BelgradeBelgradeSerbia
  8. 8.Institute of Medical Statistics, Faculty of MedicineUniversity of BelgradeBelgradeSerbia

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