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Hormones

, Volume 13, Issue 2, pp 213–221 | Cite as

Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS)

  • Neoklis A. Georgopoulos
  • Efstathios Papadakis
  • Anastasia K. Armeni
  • Ilias Katsikis
  • Nikolaos D. Roupas
  • Dimitrios Panidis
Research paper

Abstract

OBJECTIVE

To evaluate the impact of elevated serum Δ4A levels on the hormonal and metabolic features of the different phenotypes of PCOS.

DESIGN

1276 women with PCOS according to the Rotterdam criteria were included, in whom serum hormonal levels were determined.

RESULTS

In PCOS women as a whole, as well as in patients presenting clinical and/or biochemical hyperandrogenemia (phenotypes I and II), Δ4A levels >3.8 ng/ml were positively related to LH, LH/FSH ratio, T, DHEAS, 17 OH progesterone and FAI and negatively related to T/Δ4A ratio. In the milder phenotype III, a positive correlation between Δ4A levels >3.8 ng/ml and T, DHEAS, 17 OH progesterone and FAI and a negative one between increased Δ4A and T/Δ4A ratio were reported. In the whole PCOS group with androstenedione >3.8 ng/ml, an increased ovarian volume was observed, while a greater mean follicular number was found only in phenotypes I and II.

CONCLUSIONS

Increased serum Δ4A levels, which are associated with more severe PCOS phenotypes, possibly contribute to the worsening of PCOS features and therefore could be a valuable marker of biochemical hyperandrogenemia.

Key words

Adrenals Androstenedione Androstenedione/Testosterone ratio Insulin resistance PCOS 

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Copyright information

© Hellenic Endocrine Society 2014

Authors and Affiliations

  • Neoklis A. Georgopoulos
    • 1
  • Efstathios Papadakis
    • 2
  • Anastasia K. Armeni
    • 1
  • Ilias Katsikis
    • 2
  • Nikolaos D. Roupas
    • 1
  • Dimitrios Panidis
    • 2
  1. 1.Department of Obstetrics and Gynecology, Division of Reproductive EndocrinologyUniversity of Patras Medical SchoolPatrasGreece
  2. 2.Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and GynecologyAristotle University of ThessalonikiThessalonikiGreece

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