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Hormones

, Volume 12, Issue 1, pp 111–118 | Cite as

Variations of urinary iodine during the first trimester of pregnancy in an iodine-replete area. Comparison with non-pregnant women

  • Atieh Amouzegar
  • Fereidoun Azizi
Research paper

Abstract

OBJECTIVE

To assess variations of urinary iodine concentration (UIC) during a 4-week period among pregnant and non-pregnant women in an iodine-replete area.

DESIGN

Pregnant (in their first trimester of pregnancy) and non-pregnant women referred to two maternity hospitals in Tehran were consecutively recruited from September 2005 to March 2006. Urine samples (5–10 mL) were collected on an every-other-day basis for 4 weeks (i.e., 12 samples for each individual). UIC was determined using a modified Sandell-Kolthoff method.

RESULTS

Thirty-six pregnant and 32 non-pregnant women completed the study. Mean±SD age of pregnant women was 27.4±6.4 and of non-pregnant women 27.6±4.5 years (P=0.897). Mean±SD gestational age was 11±3.3 weeks in pregnant participants. Median UIC of <100, 100–149, 150–249, and ≥250 µg/L was present in 19.4, 25, 30.6, and 25% of pregnant, 15.6, 37.5, 34.4, and 12.5% of non-pregnant, and 17.6, 30.9, 32.4, and 19.1% of total individuals, respectively. Median UIC values of samples numbers 1 to 12 were not significantly different either in pregnant (P=0.591) or in non-pregnant subjects (P=0.745). Except for sample number 11, median UIC was not significantly different between pregnant versus non-pregnant women (P values >0.05). Mean SD values for UIC in samples numbers 1 to 12 in pregnant women was 138.4 (24.1–404) and in non-pregnant women 118 (29.5–272.4) ug/L (P=0.286).

CONCLUSION

There was a wide intrapersonal variation in UIC values among pregnant and non-pregnant women residing in an iodine-replete area, supporting the notion that casual UIC would not reflect the iodine status of the individual.

Key words

Daily variation Iodine Pregnancy Trimester Urine 

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References

  1. 1.
    Hetzel BS, 1983 Iodine deficiency disorders (IDD) and their eradication. Lancet 2: 1126–1129.CrossRefGoogle Scholar
  2. 2.
    Delange FM, Dunn JT, 2005 Iodine deficiency. In: Braverman LE, Utiger RD (eds) Werner and Ingbar’s The Thyroid: A fundamental and clinical text, 9th ed, Lippincott Williams and Wilkins, Philadelphia; pp, 264–288.Google Scholar
  3. 3.
    Chan S, Kilby MD, 2000 Thyroid hormone and central nervous system development. J Endocrinol 165: 1–8.CrossRefGoogle Scholar
  4. 4.
    Delange F, 2005 Epidemiology and impact of iodine deficiency in pediatrics. J Pediatr Endocrinol Metab 18: 1245–1251.CrossRefGoogle Scholar
  5. 5.
    Vitti P, Delange F, Pinchera A, Zimmermann M, Dunn JT, 2003 Europe is iodine deficient. Lancet 361: 1226.CrossRefGoogle Scholar
  6. 6.
    Guttikonda K, Burgess JR, Hynes K, Boyages S, Byth K, Parameswaran V, 2002 Recurrent iodine deficiency in Tasmania, Australia: a salutary lesson in sustainable iodine prophylaxis and its monitoring. J Clin Endocrinol Metab 87: 2809–2815.CrossRefGoogle Scholar
  7. 7.
    Delshad H, Amouzegar A, Mirmiran P, Mehran L, Azizi F, 2012 Eighteen years of continuously sustained elimination of iodine deficiency in the Islamic Republic of Iran: the vitality of periodic monitoring. Thyroid 22: 415–421.CrossRefGoogle Scholar
  8. 8.
    WHO, UNICEF, ICCIDD (eds) 2001 Assessment of the iodine deficiency disorders and monitoring their elimination: A guide for programme managers, 2nd ed, WHO/NHD/01.1, Geneva; pp, 1–107.Google Scholar
  9. 9.
    Vought RL, London WT, Lutwak L, Dublin TD, 1963 Reliability of estimates of serum inorganic iodine and daily fecal and urinary iodine excretion from single casual specimens. J Clin Endocrinol Metab 23: 1218–1228.CrossRefGoogle Scholar
  10. 10.
    Bourdoux P, 1998 Evaluation of the iodine intake: problems of the iodine/creatinine ratio—comparison with iodine excretion and daily fluctuations of iodine concentration. Exp Clin Endocrinol Diabetes 106 Suppl 3: 17–20.Google Scholar
  11. 11.
    Als C, Helbling A, Peter K, Haldimann M, Zimmerli B, Gerber H, 2000 Urinary iodine concentration follows a circadian rhythm: a study with 3023 spot urine samples in adults and children. J Clin Endocrinol Metab 85: 1367–1369.PubMedGoogle Scholar
  12. 12.
    Burgi H, Bangerter B, Siebenhuhner L, 2000 High day-to-day variability of urinary iodine excretion despite almost universal salt iodization in Switzerland. In: Geertman RM (ed) World Salt Symposium, Vol. 2, Elsevier, Amsterdam; pp, 961–963.Google Scholar
  13. 13.
    Azizi F, Sheikholeslam R, Hedayati M, et al, 2002, Sustainable control of iodine deficiency in Iran: beneficial results of the implementation of the mandatory law on salt iodization. J Endocrinol Invest 25: 409–413.CrossRefGoogle Scholar
  14. 14.
    Azizi F, Mehran L, Sheikholeslam R, et al, 2008 Sustainability of a well-monitored salt iodization program in Iran: marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt. J Endocrinol Invest 31: 422–431.CrossRefGoogle Scholar
  15. 15.
    Dunn JT, Crutchfield HE, Gutekunst R, Dunn AD, 1993 Methods for measuring iodine in urine. The Netherlands: ICCIDD/UNICEF/WHO Publications.Google Scholar
  16. 16.
    WHO technical consultation on iodine deficiency in pregnant and lactating women and children under 2 years, 2005 WHO, Geneva, 24–26 January.Google Scholar
  17. 17.
    Munro BH, 2001 Correlation. In: Munro BH (ed) Statistical methods for health care research, 4th ed, Lippincott, Philadelphia; pp, 223–243.Google Scholar
  18. 18.
    Sprent P, Smeeton NC, 2001 Other single-sample inferences. In: Sprent P, Smeeton NC (eds) Applied nonparametric statistical methods, 3rd ed, Chapman & Hall / CRC, Boca Raton; pp, 78–119.Google Scholar
  19. 19.
    Teitelbaum SL, Britton JA, Calafat AM, et al, 2008 Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the united States. Environ Res: 1062: 257–269.CrossRefGoogle Scholar
  20. 20.
    Hauser R, Meeker JD, Park S, Silva MJ, Calafat AM, 2004 Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect 112: 1734–1740.CrossRefGoogle Scholar
  21. 21.
    Rosner B 2006 Fundamentals of Biostatistics. In: (Sixth Edition). Duxbury Press, Pacific. Grove, CA.Google Scholar
  22. 22.
    Rasmussen LB, Ovesen L, Christiansen E, 1999 Day-today and within-day variation in urinary iodine excretion. Eur J Clin Nutr 53: 401–407.CrossRefGoogle Scholar
  23. 23.
    Fumée CA, van der Haar F, West CE, Hautvast JG, 1994 A critical appraisal of goiter assessment and the ratio of urinary iodine to creatinine for evaluating iodine status. Am J Clin Nutr 59: 1415–1417.CrossRefGoogle Scholar
  24. 24.
    Semba RD, Delange F, 2001 Iodine in human milk: perspectives for infant health. Nutr Rev 59: 269–278.CrossRefGoogle Scholar
  25. 25.
    Azizi F, Aminorroya A, Hedayati M, Rezvanian H, Amini M, Mirmiran P, 2003 Urinary iodine excretion in pregnant women residing in areas with adequate iodine intake. Public Health Nutr 6: 95–98.CrossRefGoogle Scholar
  26. 26.
    Ainy E, Ordookhani A, Hedayati M, Azizi F, 2007 Assessment of intertrimester and seasonal variations of urinary iodine concentration during pregnancy in an iodine-replete area. Clin Endocrinol 67: 577–581.Google Scholar
  27. 27.
    Davison JM, 1987 Kidney function in pregnant women. Am J Kidney Dis 9: 248–252.CrossRefGoogle Scholar
  28. 28.
    Pearce EN, Pino S, He X, Bazrafshan HR, Lee SL, Braverman LE, 2004 Sources of dietary iodine: bread, cows’ milk, and infant formula in the Boston area. J Clin Endocrinol Metab 89: 3421–3424.CrossRefGoogle Scholar
  29. 29.
    Als C, Haldimann M, Burgi E, Donati F, Gerber H, Zimmerli B, 2003 Swiss pilot study of individual seasonal fluctuations of urinary iodine concentration over two years: is age-dependency linked to the major source of dietary iodine? Eur J Clin Nutr 57: 636–646.CrossRefGoogle Scholar
  30. 30.
    Hess SY, Zimmermann MB, Torresani T, Burgi H, Hurrell RF, 2001 Monitoring the adequacy of salt iodization in Switzerland: a national study of school children and pregnant women. Eur J Clin Nutr 55: 162–166.CrossRefGoogle Scholar
  31. 31.
    Brander L, Als C, Buess H, et al, 2003 Urinary iodine concentration during pregnancy in an area of unstable dietary iodine intake in Switzerland. J Endocrinol Invest 26: 389–396.CrossRefGoogle Scholar
  32. 32.
    Nazeri P, Mirmiran P, Mehrabi Y, Hedayati M, Delshad H, Azizi F, 2010 Evaluation of iodine nutritional status in Tehran, Iran: iodine deficiency within iodine sufficiency. Thyroid 20: 1399–1406.CrossRefGoogle Scholar

Copyright information

© Hellenic Endocrine Society 2013

Authors and Affiliations

  1. 1.Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran

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