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Inflammation Research

, Volume 56, Supplement 3, pp S488–S491 | Cite as

PAF-induced kinin B1 receptor in vivo up-regulation: involvement of distinct kinase pathways

  • Elizabeth S. Fernandes
  • Rodrigo Medeiros
  • Maria M. Campos
  • Joao B. Calixto
Papers Submitted for the IAIS Young Investigator Award Competition Mini-Paper 2
  • 23 Downloads

Abstract

Platelet activating factor (PAF) is an important mediator in several pathophysiological processes. PAF receptor activation can causes a series of cellular and tissuemodifications and can lead to the production and/or release of diverse molecules, including cytokines, chemokines and receptors, amongst others, which are capable of amplifying the inflammation. PAF can up-regulate kinin B1 receptor expression by various mechanisms. In the present study, we show an additional mechanism by which PAF can lead to an in vivo up-regulation of B1 receptors. Our results clearly show that the phosphorylation of both ERK1/2 and JNK MAPKinases is an important step for this event. However, the exact mechanisms (transcriptional and post- transcriptional) by which PAF can trigger kinase phosphorylation and then up-regulate the B1 receptor require further investigation.

Keywords

Platelet Activate Factor SB203580 PD98059 Platelet Activate Factor Receptor Tribromoethanol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag, Basel 2007

Authors and Affiliations

  • Elizabeth S. Fernandes
    • 1
  • Rodrigo Medeiros
    • 1
  • Maria M. Campos
    • 2
  • Joao B. Calixto
    • 1
  1. 1.Department of Pharmacology, CCB, Centre of Biological SciencesUniversidade Federal de Santa Catarina, Campus UniversitarioFlorianopolisBrazil
  2. 2.School of DentistryPontificia Universidade Catolica doPorto AlegreBrazil

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