Nano-Micro Letters

, Volume 6, Issue 3, pp 258–267 | Cite as

Magnetic Fe3O4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing

  • Lili Yu
  • Hui Wu
  • Beina Wu
  • Ziyi Wang
  • Hongmei Cao
  • Congying Fu
  • Nengqin Jia
Open Access


An electrochemical biosensing platform was developed based on glucose oxidase (GOx)/Fe3O4- reduced graphene oxide (Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode (MGCE). With the advantages of the magnetism, conductivity and biocompatibility of the Fe3O4-RGO nanosheets, the nanocomposites could be facilely adhered to the electrode surface by magnetically controllable assembling and beneficial to achieve the direct redox reactions and electrocatalytic behaviors of GOx immobilized into the nanocomposites. The biosensor exhibited good electrocatalytic activity, high sensitivity and stability. The current response is linear over glucose concentration ranging from 0.05 to 1.5 mM with a low detection limit of 0.15 μM. Meanwhile, validation of the applicability of the biosensor was carried out by determining glucose in serum samples. The proposed protocol is simple, inexpensive and convenient, which shows great potential in biosensing application.


Fe3O4-reduced graphene oxide (Fe3O4-RGO) Nanocomposites Magnetically controllable assembling Direct electron transfer Biosensor 


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Copyright information

© Shanghai Jiao Tong University (SJTU) Press 2014

Authors and Affiliations

  • Lili Yu
    • 1
  • Hui Wu
    • 1
  • Beina Wu
    • 1
  • Ziyi Wang
    • 1
  • Hongmei Cao
    • 1
  • Congying Fu
    • 1
  • Nengqin Jia
    • 1
  1. 1.The Education Ministry Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, College of Life and Environmental SciencesShanghai Normal UniversityShanghaiChina

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