Catch-up growth in body mass index is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for gestational age
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Objective: Low birth weight is a risk factor for coronary heart disease. Persons who have coronary events as adults tend to have been small at birth and thin at 2 yr of age, after which they tended to increase their body mass index (BMI). Our aim was to determine whether BMI gain is associated to alterations in insulin sensitivity and/or lipid profile in children born small for gestational age (SGA). Design: Retrospective case-control study. Methods: We studied 78 children (mean age 7.8±2.5 yr): 26 SGA children with catch-up growth in BMI (CGB-SGA) (BMI= 10th to 75th centile), 26 SGA without catch-up growth (NCGB-SGA) (BMI<10th centile), and 26 appropriate for gestational age (AGA) control children (BMI: 10th to 75th centile). For each CGB-SGA child, we selected an NCGB-SGA and an AGA child of the same gender, age (with-in 1 yr), and pubertal status. SGA children were also subdivided into 2 groups according to post-natal catch-up growth in height (CGH). Results: Glucose was significantly lower in NCGBSGA than AGA group (p=0.02). No significant differences in fasting insulin, fasting glucose/insulin ratio, homeostasis model assessment, quantitative insulin-sensitivity check index, and lipid profile were found among the 3 groups. HDL-cholesterol proved significantly reduced in SGA children with post-natal CGH (p=0.02). Conclusions: Our findings do not support the hypothesis of early alterations in insulin sensitivity and lipid metabolism in CGB-SGA subjects during childhood provided that BMI remains within the normal range. Finally, the finding of reduced HDL-cholesterol levels in CGH-SGA children suggests detrimental metabolic effects of the height gain.
KeywordsBMI insulin sensitivity lipid SGA (small for gestational age)
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- 10.Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the international societies of pediatric endocrinology and the growth hormone research society. J Clin Endocrinol Metab 2007, 92: 804–10.PubMedCrossRefGoogle Scholar
- 17.Gagliardi L, Macagno F, Pedrotti D, et al. Weight, length, and head circumference at birth of a Northeastern Italian population. Report of the ad hoc committee of the Italian Society of Neonatology. Ital J Pediatr 1999, 25: 159–69.Google Scholar
- 20.Lubchenko LO, Hansman C, Boyd R. Intrauterine growth in length and head circumference as estimated from live births atgestational ages from 26 to 42 wk. Pediatrics 1966, 37: 403–8.Google Scholar
- 31.Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood glucose concentrations are reduced in children born small for gestational age (SGA), and thyroid-stimulating hormone levels are increased in SGAwith blunted postnatal catch-up growth. J Clin Endocrinol Metab 2003, 88: 2699–705.PubMedCrossRefGoogle Scholar
- 36.Evagelidou EN, Giapros VI, Challa AS, Kiortsis DN, Tsatsoulis AA, Andronikou SK. Serum adiponectin levels, insulin resistance, and lipid profile in children born small for gestational age are affected by the severity of growth retardation at birth. Eur J Endocrinol 2007, 156: 271–7.PubMedCrossRefGoogle Scholar
- 38.Tenhola S, Turpeinen U, Halonen P, Hämäläinen E, Voutilainen R. Association of serum lipid concentrations, insulin resistance index and catch-up growth with serum cortisol/cortisone ratio by liquid chromatography tandem mass spectrometry in children born small for gestational age. Pediatr Res 2005, 58: 467–71.PubMedCrossRefGoogle Scholar
- 40.Plank C, Meissner U, Rauh M, etal. Cortisol-cortisone ratios in small for gestational age (SGA) children without postnatal catch-up growth. Clin Endocrinol 2007, Epub ahead of print 2007 Jun 7; doi: 10.1111/j.1365-2265.2007.02884.xGoogle Scholar