Journal of Endocrinological Investigation

, Volume 28, Issue 11, pp 853–863 | Cite as

Type 2 diabetes mellitus in children and adolescents

  • M. Marcovecchio
  • A. Mohn
  • F. ChiarelliEmail author
Review Article


Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Prevalence of T2DM in children is mostly linked to some risk factors: obesity and sedentary lifestyle, puberty, membership of ethnic minorities, features of insulin resistance, family history of T2DM, female gender and perinatal factors. Prevention is essential and can be considered a public health approach directed to the general population. Treatment of T2DM in youth is complex and based on different strategies: diet, exercise and pharmacotherapy. An appropriated intervention program must be started early, in order to prevent or retard the progression of the disease and associated comorbidities.


T2DM insulin resistance children adolescents youth 


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Copyright information

© Italian Society of Endocrinology (SIE) 2005

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of ChietiChietiItaly

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