Journal of Endocrinological Investigation

, Volume 27, Issue 10, pp 965–966 | Cite as

A rare and asymptomatic case of mitral valve tophus associated with severe gouty tophaceous arthritis

  • G. Iacobellis
  • G. IacobellisEmail author
Case Report


Gouty arthritis is characterized by the deposition of monosodium urate crystals in the joints and soft tissues. Clinical manifestations include acute and chronic arthritis and tophaceous deposits. Chronic tophaceous gout has become less common since the introduction of the pharmacological treatment. Moreover, cardiac valve gouty tophi have been very rarely reported


Gouty arthritis cardiac valve tophus 


  1. 1.
    Gawoski JM, Balogh K, Landis WJ. Aortic valvular tophus: identification by X-ray diffraction of urate and calcium phosphates. J Clin Pathol 1985, 38: 873–6.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Jaworski RC, Gibson M. Tophaceous aortic valve: a case report. Pathology 1983, 15: 197–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Kim KM, Trump BF. Amorphous calcium precipitations in human aortic valve. Calcif Tissue Res 1975, 18: 155–60.PubMedCrossRefGoogle Scholar
  4. 4.
    Dennstedt FE, Weilbaecher DG. Tophaceous mitral valve: Report of a case. Am J Surg Pathol 1982, 6: 79–81.PubMedCrossRefGoogle Scholar
  5. 5.
    Curtiss EI, Miller TR, Shapiro LS. Pulmonic regurgitation due to valvular tophi. Circulation 1983, 67: 699–701.PubMedCrossRefGoogle Scholar
  6. 6.
    Scalapino JN, Edwards WD, Steckelberg JM, Wooten RS, Callahan JA, Ginsburg WW. Mitral stenosis associated with valvular tophi. Mayo Clin Proc 1984, 59: 509–12.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2004

Authors and Affiliations

  1. 1.Department of Clinical SciencesLa Sapienza UniversityRomeItaly
  2. 2.Department of Clinical Nutrition Center for Human NutritionUniversity of Texas Southwestern Medical CenterDallasItaly

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