Journal of Endocrinological Investigation

, Volume 30, Issue 3, pp 210–214 | Cite as

The correlation between adiposity and adiponectin, tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?

  • M. BahceciEmail author
  • D. Gokalp
  • S. Bahceci
  • A. Tuzcu
  • S. Atmaca
  • S. Arikan
Original Articles


Objective: Hypertrophic obesity correlates with metabolic complications of obesity. We evaluated adipocyte volume and its relationship with tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), adiponectin and high sensitivity C-reactive protein (hs-CRP) levels. Subjects and methods: Patients were divided into 4 groups; lean healthy controls [body mass index (BMI): 24.2±1.4 kg/m2], non-diabetic obese patients (30.2±2.9), obese (30.1 ±3.2) and non-obese (22.2±1.5) Type 2 diabetic patients. TNF-α, hs-CRP, adiponectin and IL-6 levels were measured preoperatively and sc fat specimens were obtained during operation. Semi-thin sections were stained with toluidine-blue and evaluated by light microscopy. Fat volumes were calculated by Goldrick’s formulation. Results: Mean adipocyte volumes were higher in obese diabetic patients than in other groups (p<0.0001). Mean TNF-α, hs-CRP and IL-6 levels were higher in obese diabetic patients than in control subjects, obese non-diabetic and non-obese diabetic patients (p<0.0001, p<0.02 and p<0.01. respectively). Mean TNF-α levels of non-diabetic obese patients were higher than the control group (p<0.05). Mean IL-6 levels of diabetic and non-diabetic obese patients were higher than control subjects (p<0.02 and p<0.0001, respectively). Mean adiponectin levels of control subjects were higher than non-diabetic obese, non-obese diabetic and obese-diabetic subjects (p<0.0001). Mean adiponectin levels of obese diabetic patients were lower than non-diabetic obese subjects (p<0.008). Mean hs-CRP levels were higher in diabetic patients whether they were obese or not. There was a positive correlation between adipocyte size and TNF-α (p<0.01), IL-6 (p<0.03) and hs-CRP levels (p<0.004), and negative correlation between adipocyte size, adiponectin levels (p<0.0001). Conclusions: TNF-α, IL-6 and hs-CRP levels were positively, adiponectin negatively correlated with adipocyte size. Therefore, adiposity may be an inflammatory condition.

Key Words

TNF-α IL-6 hs-CRP adiponectin adipocyte volume obesity inflammation 


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Copyright information

© Italian Society of Endocrinology (SIE) 2007

Authors and Affiliations

  • M. Bahceci
    • 1
    Email author
  • D. Gokalp
    • 1
  • S. Bahceci
    • 2
  • A. Tuzcu
    • 1
  • S. Atmaca
    • 3
  • S. Arikan
    • 1
  1. 1.Department of EndocrinologyDicle University School of MedicineDiyarbakirTurkey
  2. 2.Department of Histology and EmbryologyDicle University School of MedicineDiyarbakirTurkey
  3. 3.Department of MicrobiologyDicle University School of MedicineDiyarbakirTurkey

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