Acupuncture in clinical and experimental reproductive medicine: A review
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Background: Acupuncture has been used as treatment for infertility for hundreds of years, and recently it has been studied in male and female infertility and in assisted reproductive technologies, although its role in reproductive medicine is still debated. Aim: To review studies on acupuncture in reproductive medicine, in experimental and clinical settings. Methods: Papers were retrieved on PubMed and Google Scholar and were included in the review if at least the abstract was in English. Results There is evidence of benefit mainly when acupuncture is performed on the day of embryo transfer (ET) in the live birth rate. Benefit is also evident when acupuncture is performed for female infertility due to polycystic ovary syndrome (PCOS). There is some evidence of sperm quality improvement when acupuncture is performed on males affected by idiopathic infertility. Experimental studies suggest that acupuncture effects are mediated by changes in activity of the autonomic nervous system and stimulation of neuropeptides/neurotransmitters which may be involved in the pathogenesis of infertility. Conclusions: Acupuncture seems to have beneficial effects on live birth rate when performed on the day of ET, and to be useful also in PCOS as well as in male idiopathic infertility, with very low incidence of side effects. However, further studies are necessary to confirm the clinical results and to expand our knowledge of the mechanisms involved.
Key-wordsAcupuncture female infertility IVF male infertility nerve growth factor
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- 2.World Health Organization. Acupuncture: review and analysis of reports on controlled clinical trials. 2003.Google Scholar
- 12.Stener-Victorin E, Lundeberg T, Cajander S, et al. Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system. Reprod Biol Endocrinol 2003, 1: 33.PubMedCentralPubMedCrossRefGoogle Scholar
- 13.Manni L, Lundeberg T, Holmäng A, Aloe L, Stener-Victorin E. Effect of electro-acupuncture on ovarian expression of alpha (1)-and beta (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol 2005, 3: 21.PubMedCentralPubMedCrossRefGoogle Scholar
- 23.Xinyun H. Acupuncture plus medication for male idiopathic oligospermatic sterility. Shanghai J Acupunct Moxibustion 1998, 5: 35–7.Google Scholar
- 27.Franconi G, Mazzilli F, Elia J, De Berardinis D, Caprio M, Fabbri A. Male subfertility and acupuncture: preliminary results. J Endocrinol Invest 2009, 32 (suppl 2): 29.Google Scholar