Journal of Endocrinological Investigation

, Volume 36, Issue 10, pp 791–796

Low serum vitamin D level is associated with high risk of metabolic syndrome in post-menopausal women

Original Article

DOI: 10.1007/BF03346758

Cite this article as:
Song, H.R. & Park, C.H. J Endocrinol Invest (2013) 36: 791. doi:10.1007/BF03346758


Background: Serum vitamin D status, as indicated by 25-(OH)D, is inversely associated with glucose homeostasis, lipid profiles, and blood pressure. Evidence on the association of serum vitamin D with metabolic syndrome (MS) however, is very limited in post-menopausal women. Aim: To investigate the association between serum vitamin D and MS. Material and methods: This study was a cross-sectional study including 778 Korean adults who visited a health promotion center in a university hospital from January 2010 to May 2011. MS was defined according to the American Heart Association/National Heart, Lung, and Blood Institute criteria and the Korean Society for the Study of Obesity. MS and its individual components were assessed, as well as serum 25-(OH)D levels with a multiple logistic regression analysis. Results: The overall prevalence of the MS in participants of this study was 147 (18.9%). After multiple adjustments, compared with the highest quartile serum 25-(OH)D level group (19.9–55.9 ng/ml), the odds ratio for MS in the lowest level group (4.2–9.7 ng/ml) was 2.44 [95% confidence interval (CI)=1.32–4.48], in the lower level group (9.8–14.1 ng/ml) was 2.20 (95% CI=1.24–3.90), and in the intermediate level group (14.3–19.8 ng/ml) was 1.81 (95% CI=1.02–3.20). Among the components of MS, the adjusted odds ratios for having an elevated blood pressure, and high triglyceride level in the lowest level group were 1.81 (95% CI, 1.15–2.85), 2.74 (95% CI, 1.64–4.57), respectively. Conclusions: We found that a low serum 25-(OH)D level is significantly associated with the presence of MS and some metabolic components, especially the high triglyceride level and blood pressure in post-menopausal women.


Abdominal obesity hypertension impaired fasting glucose metabolic syndrome vitamin D 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Italian Society of Endocrinology (SIE) 2013

Authors and Affiliations

  1. 1.Department of Epidemiology, Graduate School of Public HealthSeoul National UniversitySeoulKorea
  2. 2.Department of Preventive Medicine, College of MedicineChungbuk National UniversityCheongjuKorea
  3. 3.Department of Family Medicine, College of MedicineEulji UniversityDaejeonKorea
  4. 4.DaejeonRepublic of Korea

Personalised recommendations