Thyroid safety in patients treated with liraglutide
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During the last years, various novel anti-diabetic drugs have considerably enriched the therapeutic armamentarium for subjects with Type 2 diabetes. In the meantime, much interest has recently been focused on the potential cardiovascular and oncological adverse effects of these new therapies. As to glucagon-like peptide 1 (GLP-1) analogs, medullary thyroid tumors were reported to be more common in rodent toxicology studies with liraglutide, although the relevance of this finding in humans has been questioned. Analyses of sequential changes in calcitonin levels in several thousands of subjects did not reveal a relationship between liraglutide therapy and plasma calcitonin. Furthermore, no medullary thyroid cancer has been detected in humans taking liraglutide. Nevertheless, the long-term consequences of sustained GLP-1 receptor activation in the human thyroid remain unknown and deserve further investigation.
Key-wordsLiraglutide medullary thyroid cancer safety thyroid cancer Type 2 diabetes
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- 4.Novo Nordisk. Liraglutide (injection) for the treatment of patients with type 2 diabetes. NDA 22-341. Briefing document. Endocrine and Metabolic Drug Advisory Committee, 2 April 2009. http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/endocrinologicandmetabolicdrugsadvisorycommittee/ucm148659.pdf. Accessed January 4, 2012.
- 5.Inzucchi SE, Bergenstal RM, Buse JB, et al; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012, 35: 1364–79.PubMedCentralPubMedCrossRefGoogle Scholar
- 8.Waugh N, Cummins E, Royle P, et al. Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation. Health Technol Assess 2010, 14: 1–248.Google Scholar
- 15.Wadden TA, Hollander P, Klein S, et al. Liraglutide Provides Weight Maintenance and Additional Weight Loss after Low Calorie Diet-Induced Weight Loss in Obese Subjects without Diabetes: The SCALE™ Maintenance Study. Diabetes 2011, 60: 1859–P. American Diabetes Association (ADA) 71st Scientific Sessions, San Diego, CA, 2011 (abstract).CrossRefGoogle Scholar
- 31.Bydureon (exenatide) Product Information. 17/06/2011 Bydureon-EMEA/H/C/002020. Summary of Product Characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002020/WC500108241.pdf. Accessed January 4, 2012.
- 33.Hegedüs L, Moses AC, Zdravkovic M, Le Thi T, Daniels GH. GLP-1 and Ct concentration in humans: lack of evidence of Ct release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J Clin Endocrinol Metab 2011, 96: 853–60.PubMedCrossRefGoogle Scholar
- 38.Thurston V, Williams ED. Experimental induction of C cell tumours in thyroid by increased dietary content of vitamin D3. Acta Endocrinol (Copenh) 1982, 100: 41–5.Google Scholar
- 40.Important drug warning concerning Victoza®. Subject: potential risks of thyroid C-cell tumours and acute pancreatitis associated with Victoza®. http://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/UCM258828.pdf. Accessed January 4, 2012.
- 42.Waser B, Beetschen K, Pellegata NS, Reubi JC. Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: relevance for incretin-based diabetes therapy. Neuro-endocrinology 2011, 94: 291–301.Google Scholar