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Journal of Endocrinological Investigation

, Volume 32, Issue 7, pp 606–610 | Cite as

The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus

  • Á. G. TabákEmail author
  • G. Tamás
  • A. Péterfalvi
  • Z. Bosnyák
  • E. Madarász
  • I. Rákóczi
  • Z. Kerényi
Original Articles

Abstract

Background: There is an ongoing debate whether maternal diabetes is a more important risk factor for gestational diabetes (GDM) development than paternal diabetes. Aim: To describe the risk of GDM associated with paternal and maternal diabetes, and to further characterise GDM women with maternal diabetes. Subjects and methods: Case-control study within a population-based GDM screening program in an urban area of Hungary in 2002–2003. All GDM women (no.=133) and an age-matched control group (no.=135) with a mean age of 31 years was evaluated. Blood pressure, anthropometric data, and blood glucose values from a 75 g Oral Glucose Tolerance Test (OGTT) were recorded at 24–28 weeks of gestation. Family history data were by self-report. Results: Known paternal diabetes was not related to GDM risk [odds ratio (OR) 0.83, 95% confidence interval (CI) 0.35−2.00]. Known maternal diabetes (OR 2.90, 95% CI 0.99−8.49) and diabetes in the maternal line (OR 2.83, 95% CI 1.16–6.89) were both related to GDM after adjustment for body mass index (BMI). GDM women with known maternal diabetes had a higher BMI, 31.6 [9.1] kg/m2 median [interquartile range], than GDM women with or without diabetes in the maternal line, 26.1 [4.9] and 26.3 [6.1] kg/m2, respectively, while figures for fasting glucose during OGTT were 5.2 [0.7] vs 4.4 [1.1] vs 4.9 [0.8] mmol/l respectively (all p<0.05). Conclusions: Maternal history of diabetes and history of diabetes in the maternal line seems to be a stronger predictor of GDM than paternal history.

Key-words

Family history assessment gestational diabetes mellitus nested case-control design risk factors 

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References

  1. 1.
    Alcolado JC, Laji K, Gill-Randall R. Maternal transmission of diabetes. Diabet Med 2002, 19: 89–98.PubMedCrossRefGoogle Scholar
  2. 2.
    Karter AJ, Rowell SE, Ackerson LM, et al. Excess maternal transmission of type 2 diabetes. The Northern California Kaiser Permanente Diabetes Registry. Diabetes Care 1999, 22: 938–43.PubMedCrossRefGoogle Scholar
  3. 3.
    Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes 2000, 49: 2201–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Young CA, Kumar S, Young MJ, Boulton AJ. Excess maternal history of diabetes in Caucasian and Afro-origin non-insulin-dependent diabetic patients suggests dominant maternal factors in disease transmission. Diabetes Res Clin Pract 1995, 28: 47–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Bensen JT, Liese AD, Rushing JT, et al. Accuracy of proband reported family history: the NHLBI Family Heart Study (FHS). Genet Epidemiol 1999, 17: 141–50.PubMedCrossRefGoogle Scholar
  6. 6.
    Onyemere KU, Lipton RB. Parental history and early-onset type 2 diabetes in African Americans and Latinos in Chicago. J Pediatr 2002,141: 825–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Thorand B, Liese AD, Metzger MH, Reitmeir P, Schneider A, Lowel H. Can inaccuracy of reported parental history of diabetes explain the maternal transmission hypothesis for diabetes? Int J Epidemiol 2001, 30: 1084–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Harder T, Franke K, Kohlhoff R, Plagemann A. Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I. Gynecol Obstet Invest 2001, 51: 160–4.PubMedCrossRefGoogle Scholar
  9. 9.
    McLean M, Chipps D, Cheung NW. Motherto child transmission of diabetes mellitus: does gestational diabetes program Type 2 diabetes in the next generation? Diabet Med 2006, 23: 1213–5.PubMedCrossRefGoogle Scholar
  10. 10.
    Savona-Ventura C, Chircop M. Birth weight influence on the subsequent development of gestational diabetes mellitus. Acta Diabetol 2003, 40: 101–4.PubMedCrossRefGoogle Scholar
  11. 11.
    Schranz AG, Savona-Ventura C. Long-term significance of gestational carbohydrate intolerance: a longitudinal study. Exp Clin Endocrinol Diabetes 2002, 110: 219–22.PubMedCrossRefGoogle Scholar
  12. 12.
    Ouyang F, Shen F, Jiang F, Hu H, Pan M. [Risk factors in women with gestational diabetes mellitus]. Zhonghua Yu Fang Yi Xue Za Zhi 2002, 36: 378–81.PubMedGoogle Scholar
  13. 13.
    Murabito JM, Nam BH, D’Agostino RB Sr, Lloyd-Jones DM, O’Donnell CJ, Wilson PW. Accuracy of offspring reports of parental cardiovascular disease history: the Framingham Offspring Study. Ann Intern Med 2004, 140: 434–40.PubMedCrossRefGoogle Scholar
  14. 14.
    Albert KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998, 15: 539–53.CrossRefGoogle Scholar
  15. 15.
    Kerényi Z, Péterfalvi A, Bosnyák Z, et al. Incidence of gestational diabetes mellitus: results of a validated universal screening. Diabetologia 2004, 47: A104.CrossRefGoogle Scholar
  16. 16.
    Thomas F, Balkau B, Vauzelle-Kervroedan F, Papoz L Maternal effect and familial aggregation in NIDDM. The CODIAB Study. CO-DIAB-INSERM-ZENECA Study Group. Diabetes 1994, 43: 63–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Bjornholt JV, Erikssen G, Liestol K, Jervell J, Thaulow E, Erikssen J. Type 2 diabetes and maternal family history — An impact beyond slow glucose removal rate and fasting hyperglycemia in low-risk individuals? Results from 22.5 years of follow-up of healthy nondiabetic men. Diabetes Care 2000, 23: 1255–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Kelly LA, Lane CJ, Weigensberg MJ, et al. Parental history and risk of type 2 diabetes in overweight Latino adolescents — A longitudinal analysis. Diabetes Care 2007, 30: 2700–5.PubMedCrossRefGoogle Scholar
  19. 19.
    Fetita LS, Sobngwi E, Serradas P, Calvo F, Gautier JF. Review: Consequences of fetal exposure to maternal diabetes in offspring. J Clin Endocrinol Metab 2006, 91: 3718–24.PubMedCrossRefGoogle Scholar
  20. 20.
    Simmons D, Gatland BA, Leakehe L, Fleming C. Frequency of diabetes in family members of probands with non-insulin-dependent diabetes mellitus. J Intern Med 1995, 237: 315–21.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 2009

Authors and Affiliations

  • Á. G. Tabák
    • 1
    • 2
    Email author
  • G. Tamás
    • 1
    • 2
  • A. Péterfalvi
    • 1
    • 3
  • Z. Bosnyák
    • 1
    • 4
  • E. Madarász
    • 1
    • 2
  • I. Rákóczi
    • 5
  • Z. Kerényi
    • 1
    • 3
  1. 1.Department of Epidemiology and Public HealthUniversity College LondonLondonUK
  2. 2.1st Department of MedicineSemmelweis University Faculty of MedicineHungary
  3. 3.Csepel Health Service, DiabetologySzent Imre HospitalBudapestHungary
  4. 4.Ferencváros Health Service, DiabetologySzent Imre HospitalBudapestHungary
  5. 5.Department of Obstetrics and GynaecologySzent Imre HospitalBudapestHungary

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