Journal of Endocrinological Investigation

, Volume 32, Issue 7, pp 606–610 | Cite as

The effect of paternal and maternal history of diabetes mellitus on the development of gestational diabetes mellitus

  • Á. G. TabákEmail author
  • G. Tamás
  • A. Péterfalvi
  • Z. Bosnyák
  • E. Madarász
  • I. Rákóczi
  • Z. Kerényi
Original Articles


Background: There is an ongoing debate whether maternal diabetes is a more important risk factor for gestational diabetes (GDM) development than paternal diabetes. Aim: To describe the risk of GDM associated with paternal and maternal diabetes, and to further characterise GDM women with maternal diabetes. Subjects and methods: Case-control study within a population-based GDM screening program in an urban area of Hungary in 2002–2003. All GDM women (no.=133) and an age-matched control group (no.=135) with a mean age of 31 years was evaluated. Blood pressure, anthropometric data, and blood glucose values from a 75 g Oral Glucose Tolerance Test (OGTT) were recorded at 24–28 weeks of gestation. Family history data were by self-report. Results: Known paternal diabetes was not related to GDM risk [odds ratio (OR) 0.83, 95% confidence interval (CI) 0.35−2.00]. Known maternal diabetes (OR 2.90, 95% CI 0.99−8.49) and diabetes in the maternal line (OR 2.83, 95% CI 1.16–6.89) were both related to GDM after adjustment for body mass index (BMI). GDM women with known maternal diabetes had a higher BMI, 31.6 [9.1] kg/m2 median [interquartile range], than GDM women with or without diabetes in the maternal line, 26.1 [4.9] and 26.3 [6.1] kg/m2, respectively, while figures for fasting glucose during OGTT were 5.2 [0.7] vs 4.4 [1.1] vs 4.9 [0.8] mmol/l respectively (all p<0.05). Conclusions: Maternal history of diabetes and history of diabetes in the maternal line seems to be a stronger predictor of GDM than paternal history.


Family history assessment gestational diabetes mellitus nested case-control design risk factors 


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Copyright information

© Italian Society of Endocrinology (SIE) 2009

Authors and Affiliations

  • Á. G. Tabák
    • 1
    • 2
    Email author
  • G. Tamás
    • 1
    • 2
  • A. Péterfalvi
    • 1
    • 3
  • Z. Bosnyák
    • 1
    • 4
  • E. Madarász
    • 1
    • 2
  • I. Rákóczi
    • 5
  • Z. Kerényi
    • 1
    • 3
  1. 1.Department of Epidemiology and Public HealthUniversity College LondonLondonUK
  2. 2.1st Department of MedicineSemmelweis University Faculty of MedicineHungary
  3. 3.Csepel Health Service, DiabetologySzent Imre HospitalBudapestHungary
  4. 4.Ferencváros Health Service, DiabetologySzent Imre HospitalBudapestHungary
  5. 5.Department of Obstetrics and GynaecologySzent Imre HospitalBudapestHungary

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