Journal of Endocrinological Investigation

, Volume 31, Issue 7, pp 656–659 | Cite as

Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat

  • T. IwasaEmail author
  • T. Matsuzaki
  • M. Murakami
  • F. Shimizu
  • A. Kuwahara
  • T. Yasui
  • M. Irahara
Original Articles


Kisspeptin and its corresponding receptor, the G protein-coupled receptor 54, play an important role in reproductive systems. It has been suggested that reproductive disorders in metabolically disrupted animals are caused by the alteration of hypothalamic KiSS-1 systems. Immune/inflammatory challenge is also known to disrupt reproductive function. However, the effects of immune/inflammatory challenge on KiSS-1 systems have not been investigated. In this study, we showed that lipopolysaccharide (LPS) injection decreased hypothalamic KiSS-1 mRNA expression as well as plasma LH levels in ovariectomized rats. Indomethacin completely blocked the suppressive effects of LPS on LH secretion and KiSS-1 mRNA level. Furthermore, we showed that iv injection of kisspeptin increased plasma LH levels in LPS-administrated rats to the same degree as in saline-injected rats. These results suggest that KiSS-1 systems are sensitive to immune/inflammatory challenge conditions and transmit these signals into the central reproductive system.


GPR54 kisspeptin LH stress 


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Copyright information

© Italian Society of Endocrinology (SIE) 2008

Authors and Affiliations

  • T. Iwasa
    • 1
    Email author
  • T. Matsuzaki
    • 1
  • M. Murakami
    • 1
  • F. Shimizu
    • 1
  • A. Kuwahara
    • 1
  • T. Yasui
    • 1
  • M. Irahara
    • 1
  1. 1.Department of Obstetrics and Gynecology, Institute of Health BiosciencesThe University of Tokushima Graduate SchoolTokushimaJapan

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