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Journal of Endocrinological Investigation

, Volume 26, Issue 4, pp 359–363 | Cite as

Development of a meningioma in a patient with acromegaly during octreotide treatment: Are there any causal relationships?

  • E. De Menis
  • G. Tulipano
  • S. Villa
  • D. Billeci
  • C. Bonfanti
  • P. Pollara
  • P. Pauletto
  • Andrea Giustina
Case Report

Abstract

Somatostatin receptors are highly expressed in almost all meningiomas but in this setting their functional role is not clear. A 59-yrold woman had been treated with octreotide after an unsuccessful operation for a GH-secreting pituitary adenoma. After 8 yr of treatment, a nuclear magnetic resonance (NMR) scan disclosed a 3 cm meningioma of the tentorium. Mean GH was 2.2 ng/ml and IGF-I 325 ng/ml. Meningioma was resected and tissue was digested to obtain tumor cell suspension. Aim of the study was to measure epidermal growth factor (EGF)-induced proliferation of cultured meningioma cells in the presence of either somatostatin or octreotide. Cells were grown to semiconfluency in Dolbecco’s modified eagle medium (D-MEM) supplemented with 10% fetal calf serum (FCS). After 48 h in D-MEM without serum, the medium was replaced by fresh medium plus recombinant EGF (10 ng/ml) and somatostatin or octreotide were added in the final concentrations of 1,10 and 100 nM. 20 h later 1 μcgCi of 3H-thymidine was added to each well. After 4 h, incorporated radioactivity was measured. While octreotide did not influence significantly cell growth at the three dose tested, somatostatin increased thymidine incorporation dose-dependently (peak 100nM: 150%±27% vs medium plus EGF, p<0.05). Octreotide effectively suppressed GH secretion in our acromegalic patient but is unlikely that its long-term use could have stimulated the growth of meningioma since it did not significantly influence the in vitro proliferation of the meningioma cells. These results suggest that somatostatin-mediated proliferative effect on meningioma cells is not mediated by the subtype 2 of the somatostatin receptor.

Key-words

acromegaly meningioma somatostatin octreotide somatostatin receptors 

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Copyright information

© Italian Society of Endocrinology (SIE) 2003

Authors and Affiliations

  • E. De Menis
    • 1
  • G. Tulipano
    • 3
  • S. Villa
    • 3
  • D. Billeci
    • 2
  • C. Bonfanti
    • 4
  • P. Pollara
    • 4
  • P. Pauletto
    • 1
  • Andrea Giustina
    • 3
  1. 1.Department of Internal MedicineUniversity of BresciaBresciaItaly
  2. 2.Division of Neurosurgery, Hospital of TrevisoUniversity of BresciaBresciaItaly
  3. 3.Endocrine Section, Department of Internal MedicineUniversity of BresciaBresciaItaly
  4. 4.Institute of Microbiology, Department of Biomedical Sciences and BiotechnologiesUniversity of BresciaBresciaItaly

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