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L’Endocrinologo

, Volume 10, Issue 2, pp 52–59 | Cite as

Orticaria e tireopatie autoimmuni

  • Marcello BagnascoEmail author
  • Paola Lucia Minciullo
  • Mara Schiavo
  • Rosaria Maddalena Ruggeri
  • Sebastiano Gangemi
  • Salvatore Benvenga
Article
  • 31 Downloads

Riassunto

Nel 75% dei casi la causa dell’orticaria cronica rimane ignota (orticaria cronica idiopatica, OCI). LOCI può associarsi a malattie autoimmuni o a positività per autoanticorpi. In questo articolo tratteremo dell’associazione dell’OCI con la patologia tiroidea autoimmune e le relative possibili conseguenze sul piano clinico-terapeutico.

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Bibliografia

  1. 1.
    Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 37: 631, 2007.PubMedCrossRefGoogle Scholar
  2. 2.
    Grattan CE, Humphreys F; British Association of Dermatologists Therapy Guidelines and Audit Subcommittee. Guidelines for evaluation and management of urticaria in adults and children. Br J Dermatol 157: 1116, 2007.PubMedCrossRefGoogle Scholar
  3. 3.
    Pigatto P, Valsecchi RH. Le orticarie. In: Zanussi C (Eds.) Trattato italiano di allergologia. Selecta Medica, Pavia, 2002, p 842.Google Scholar
  4. 4.
    Kulthanan K, Jiamton S, Thumpimukvatana N, Pinkaew S. Chronic idiopathic urticaria: prevalence and clinical course. J Dermatol 34: 294, 2007.PubMedCrossRefGoogle Scholar
  5. 5.
    Rottem M. Chronic urticaria and autoimmune thyroid disease: is there a link? Autimmun Rev 2: 69, 2003.CrossRefGoogle Scholar
  6. 6.
    Dreskin SC, Andrews KY. The thyroid and urticaria. Curr Opin Allergy Clin Immunol 5: 408, 2005.PubMedCrossRefGoogle Scholar
  7. 7.
    Chapman EW, Maloof F. Bizzarre clinical manifestations of hyperthyroidism. N Engl J Med 1: 254, 1956.Google Scholar
  8. 8.
    Caratati CM, Richardson DR, Wood BT, Cawley EP. Cutaneous manifestations of hyperthyroidism. South Med J 62: 1127, 1969.CrossRefGoogle Scholar
  9. 9.
    Isaac NJ, Ertel NH. Urticaria and pruritus: uncommon manifestations of hyperthyroidism. J Allergy Clin Immunol 48: 73, 1971.CrossRefGoogle Scholar
  10. 10.
    Leznoff A, Josse RG, Denberg J, Dolovich J. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol 119: 636, 1983.PubMedCrossRefGoogle Scholar
  11. 11.
    Leznoff A, Sussman GL. Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients. J Allergy Clin Immunol 84: 66, 1989.PubMedCrossRefGoogle Scholar
  12. 12.
    Gaig P, García-Ortega P, Enrique E, Richart C. Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity. J Investig Allergol Clin Immunol 10: 342, 2000.PubMedGoogle Scholar
  13. 13.
    Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME. Are autoantibodies present in patients with subacute and chronic urticaria? J Investig Allergol Clin Immunol 11: 16, 2001.PubMedGoogle Scholar
  14. 14.
    Zauli D, Deleonardi G, Foderaro S, Grassi A, Bortolotti R, Ballardini G, Bianchi FB. Thyroid autoimmunity in chronic urticaria. Allergy Asthma Proc 22: 93, 2001.PubMedCrossRefGoogle Scholar
  15. 15.
    Lombardo G, Gangemi S, Merendino RA, Forestieri A, Bertuccio O, Minciullo PL, Ferlazzo B. Associazione tra tireopatia autoimmune e orticaria cronica idiopatica: considerazioni suggerite da una casistica personale. It J Allergy Clin Immunol 12: 17, 2002.Google Scholar
  16. 16.
    Gangemi S, Saitta S, Lombardo G, Patafi M, Benvenga S. Serum thyroid autoantibodies in patients with idiopathic either acute or chronic urticaria. J Endocrinol Invest 32: 107, 2009.PubMedGoogle Scholar
  17. 17.
    Benvenga S, Trimarchi F. Changed presentation of Hashimoto’s thyroiditis in North-Eastern Sicily and Calabria (Southern Italy) based on a 31-year experience. Thyroid 18: 429, 2008.PubMedCrossRefGoogle Scholar
  18. 18.
    Fusari A, Colangelo C, Bonifazi F, Antonicelli L. The autologus serum skin test in the follow-up of patients with chronic urticaria. Allergy 60: 256, 2005.PubMedCrossRefGoogle Scholar
  19. 19.
    Cebeci F, Tanrikut A, Topcu E, Onsun N, Kurtulmus N, Uras AR. Association between chronic urticaria and thyroid autoimmunity. Eur J Dermatol 4: 402, 2006.Google Scholar
  20. 20.
    Verneuil L, Leconte C, Ballet JJ, Coffin C, Laroche D, Izard JP, Reznik Y, Leroy D. Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients. Dermatology 208: 98, 2004.PubMedCrossRefGoogle Scholar
  21. 21.
    Palma-Carlos AG, Palma-Carlos ML. Chronic urticaria and thyroid auto-immunity. Eur Ann Allergy Clin Immunol 37: 143, 2005.PubMedGoogle Scholar
  22. 22.
    Asero R, Orsatti A, Tedeschi A, Lorini M.J. Autoimmune chronic urticaria associated with type 1 diabetes and Graves’ disease. Allergy Clin Immunol. 115: 1088, 2005. Comment in: J Allergy Clin Immunol 108: 874, 2001.CrossRefGoogle Scholar
  23. 23.
    Irani C, Gordon ND, Zweiman B, Levinson AI. Chronic urticaria/angioedema and Graves’ disease: Coexistence of 2 antireceptor antibody-mediated diseases. J Allergy Clin Immunol 108: 874, 2001. Comment in: J Allergy Clin Immunol 115: 1088, 2005.PubMedCrossRefGoogle Scholar
  24. 24.
    Losa García JE, Pérez Losada J, Martín de Cabo MR, Sánchez Sánchez R, González Villarón L. Acquired angioneurotic edema associated with Graves’ disease and vitiligo. An Med Interna 16: 106, 1999.PubMedGoogle Scholar
  25. 25.
    Collet E, Petit JM, Lacroix M, Bensa AF, Morvan C, Lambert D. Chronic urticaria and autoimmune thyroid diseases. Ann Dermatol Venereol 122: 413, 1995. Comment in: Ann Dermatol Venereol 123: 124, 1996.PubMedGoogle Scholar
  26. 26.
    Altus P, Blandon R, Wallach PM, Flannery MT. Case report: the spectrum of autoimmune thyroid disease with urticaria. Am J Med Sci 306: 379, 1993.PubMedCrossRefGoogle Scholar
  27. 27.
    Cailleba A, Andre P, Thieblot P, Lauras H, Moinade S. Rare association of urticaria and Basedow’s disease. Presse Med 13: 942, 1984.PubMedGoogle Scholar
  28. 28.
    Carvalho P. In which circumstances does the description of an etiology affect the treatment and the course of chronic urticaria? Ann Dermatol Venereol 130, Spec No 1: 1S121, 2003.PubMedGoogle Scholar
  29. 29.
    Patella V, Fittipaldi MR, Florio G, Lettieri G, Nicoletti A. Tiroidite autoimmune e orticaria cronica: quali associazioni? It J Allergy Clin Immunol 16: 129, 2006.Google Scholar
  30. 30.
    Aversano M, Caiazzo P, Iorio G, Ponticiello L, Laganà B, Leccese F. Improvement of chronic idiopathic urticaria with L-thyroxine: a new TSH role in immune response? Allergy 60: 489, 2005.PubMedCrossRefGoogle Scholar
  31. 31.
    Rumbyrt JS, Katz JL, Schocket AL. Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol 96: 901, 1995.PubMedCrossRefGoogle Scholar
  32. 32.
    Koh CK, Hew FL, Chiu CL. Treatment of chronic urticaria with thyroxine in an euthyroid patient with thyreoglubulin and microsomal antibodies. Ann Acad Med Singapore 29: 528, 2000.PubMedGoogle Scholar
  33. 33.
    Kandeel AA, Zeid M, Helm T, Lillie MA, Donahue E, Ambrus JL Jr. Evaluation of chronic urticaria in patients with Hashimoto thyroiditis. J Clin Immunol 21: 335, 2001.PubMedCrossRefGoogle Scholar
  34. 34.
    Eckman JA, Hamilton RG, Gober LM, Sterba PM, Saini SS. Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. J Invest Dermatol 128: 1956, 2008.PubMedGoogle Scholar
  35. 35.
    Sabroe RA, Grattan CE, Francis DM, Barr RM, Kobza Black A, Greaves MW. The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol 140: 446, 1999.PubMedCrossRefGoogle Scholar
  36. 36.
    Vermeulen C, Mathelier-Fusade P, Rouquette AM, Bayrou O, Pecquet C, Leynadier F. Chronic urticaria, thyroiditis and autologous serum test. Ann Dermatol Venereol 130: 1115, 2003.PubMedGoogle Scholar
  37. 37.
    Bassini M, Ridolo E, Dall’Aglio P. La syndrome orticaria cronica idiopaticaangioedema (CIU-A) e il test cutaneo con siero autologo (ASST): aspetti clinico-laboratoristici. It J Allergy Clin Immunol 13: 88, 2003.Google Scholar
  38. 38.
    Kaplan AP. Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol 114: 465, 2004.PubMedCrossRefGoogle Scholar
  39. 39.
    Nielsen CH, Hegedüs L, Leslie RG. Autoantibodies in autoimmune thyroid disease promote immune complex formation- with self antigens and increase B cell and CD4 + T cell proliferation in response to self antigens. Eur J Immunol 34: 263, 2004.PubMedCrossRefGoogle Scholar
  40. 40.
    Blanchin S, Estienne V, Durand-Gorde JM, Carayon P, Ruf J. Complement activation by direct C4 binding to thyroperoxidase in Hashimoto’s thyroiditis. Endocrinology 144: 5422, 2003PubMedCrossRefGoogle Scholar
  41. 41.
    Concha LB, Chang CC, Szema AM, Dattwyler RJ, Carlson HE. IgE antithyroid antibodies in patients with Hashimoto’s disease and chronicurticaria. Allergy Asthma Proc 25: 293, 2004.PubMedGoogle Scholar
  42. 42.
    Bangash SA, Bahna SL. Resolution of chronic urticaria and angioedema with thyroxine. Allergy Asthma Proc 26: 415, 2005.PubMedGoogle Scholar
  43. 43.
    Miralles JC, Soriano J, Negro JM. Facial edema associated with thyroid autoimmunity. Allergol Immunopathol (Madr) 30: 47, 2002.CrossRefGoogle Scholar
  44. 44.
    Amoroso A, Garzia P, Pasquarelli C, Sportelli G, Afeltra A. Hashimoto’s thyroiditis associated with urticaria and angio-oedema: disappearance of cutaneous and mucosal manifestations after thyroidectomy. J Clin Pathol 50: 254, 1997.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2009

Authors and Affiliations

  • Marcello Bagnasco
    • 1
    Email author
  • Paola Lucia Minciullo
    • 2
  • Mara Schiavo
    • 1
  • Rosaria Maddalena Ruggeri
    • 3
  • Sebastiano Gangemi
    • 2
  • Salvatore Benvenga
    • 3
    • 4
    • 5
  1. 1.Terapia Medica e Radiometabolica, Dipartimento di Patologie Immunoendocrinologiche, Azienda Ospedale-Università S. Martino-DiMIUniversità degli Studi di GenovaGenovaItalia
  2. 2.U.O.C. e Scuola di Allergologia e Immunologia ClinicaPoliclinico UniversitarioMessinaItalia
  3. 3.Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e FarmacologiaUniversità di MessinaMessinaItalia
  4. 4.Master di Endocrinologia dell’Infanzia, dell’Adolescenza e della DonnaUniversità di MessinaMessinaItalia
  5. 5.Programma di Endocrinologia Molecolare ClinicaA.O.U. Policlinico G. MartinoMessinaItalia

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