Journal of Endocrinological Investigation

, Volume 29, Issue 8, pp RC13–RC15

Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats

  • L. M. Seoane
  • O. Al-Massadi
  • Y. Pazos
  • U. Pagotto
  • F. F. Casanueva
Rapid Communication


The isolation of ghrelin unveiled a new system implicated in food intake regulation. The recently isolated hormone obestatin derives from the same precursor of ghrelin and seems to perform opposite actions. It could be part of a dual system connecting gut and brain to regulate energy homeostasis. The ability of intracerebroventricular administration of obestatin to modify food intake was evaluated. Obestatin had no effect on spontaneous food intake in both ad libitum and food restricted rats. The obestatin injection was not able to antagonize the ghrelin-stimulated increase in food intake either. In conclusion, the present work does not support a role for obestatin on the regulation of food intake in any model studied.


Obestatin ghrelin food-intake energy homeostasis appetite 


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Copyright information

© Italian Society of Endocrinology (SIE) 2006

Authors and Affiliations

  • L. M. Seoane
    • 1
  • O. Al-Massadi
    • 2
  • Y. Pazos
    • 1
  • U. Pagotto
    • 3
  • F. F. Casanueva
    • 1
    • 2
  1. 1.Endocrinología Molecular, Área de Investigación, Complejo Hospitalario Universitario de Santiago (CHUS)Santiago de CompostelaSpain
  2. 2.Department of MedicineSantiago de Compostela UniversitySantiago de CompostelaSpain
  3. 3.Endocrinology UnitSant’Orsola-Malpighi HospitalBolognaItaly

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