Journal of Endocrinological Investigation

, Volume 29, Issue 6, pp 511–515

A very high incidence of low 25 hydroxy-vitamin D serum concentration in a French population of patients with primary hyperparathyroidism

  • P. Boudou
  • F. Ibrahim
  • C. Cormier
  • E. Sarfati
  • J. C. Souberbielle
Original Articles

Abstract

Since the demonstration that vitamin D status might influence the clinical and biological expression of primary hyperparathyroidism (PHPT), a serum 25-hydroxy vitamin D (25-OHD) concentration of 50 nmol/l has been considered by an expert panel as the minimum level to be maintained in asymptomatic PHPT patients. Two yr after this recommendation, we aimed to evaluate the frequency of serum 25-OHD concentrations below this threshold in PHPT patients. In the present study, serum 25-OHD, second- and third-generation PTH, calcium, phosphate, magnesium, albumin and creatinine were measured in 72 out 145 consecutive PHPT patients operated on in our Endocrine Surgery Department, in whom blood samples were available before as well as two days after surgical intervention. Before surgery, the frequency of serum 25-OHD levels <50 nmol/l ranged from 91.5 to 100% whatever the classification used to identify patients: whole group, symptomatic vs asymptomatic, patients with calcium levels >3 vs >3 mmol/l. 25-OHD concentrations correlated negatively with the weight of adenoma, PTH levels, and total calcium concentrations measured before surgery. Pre-operative PTH levels, whatever the assay used, and total calcium concentrations were positively and significantly correlated. Two days post-surgery, 13 patients were moderately hypocalcemic. Neither pre-surgery 25-OHD nor PTH, calcium or phosphorus level or adenoma weight were predictive of post-operative hypocalcemia. The dramatic frequency of low 25-OHD concentrations in our PHPT patients demonstrates that the above-mentioned recommendation is far from being applied in France despite evidence of worsening expression of PHPT with decreasing 25-OHD serum levels.

Key-words

Primary hyperparathyroidism vitamin D parathyroid hormone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Italian Society of Endocrinology (SIE) 2006

Authors and Affiliations

  • P. Boudou
    • 1
    • 5
  • F. Ibrahim
    • 1
  • C. Cormier
    • 2
  • E. Sarfati
    • 3
  • J. C. Souberbielle
    • 4
  1. 1.Department of Hormonal BiologySaint-Louis University Hospital (AP-HP) and INSERM U671Paris cedex 10France
  2. 2.Department of RhumatologyHôpital CochinFrance
  3. 3.Endocrine Surgeryhôpital Saint-LouisFrance
  4. 4.Physiology laboratory, Hôpital Necker-Enfants malades, Assistance PubliqueHôpitaux de Paris (AP-HP)France
  5. 5.INSERMParisFrance

Personalised recommendations