Journal of Endocrinological Investigation

, Volume 25, Issue 11, pp 1006–1019 | Cite as

Disorders of ejaculation

  • E. A. JanniniEmail author
  • C. Simonelli
  • A. Lenzi
Review Article


The physiology of ejaculation includes emission of sperm with the accessory gland fluid into the urethra, simultaneous closure of the ure-thral sphincters, and forceful ejaculation of semen through the urethra. Emission and closure of the bladder neck are primarily α-adrenergically mediated thoracolumbar sympathetic reflex events with supraspinal modulation. Ejaculation is a sacralspinal reflex mediated by the pudendal nerve. The most common ejaculation disorder is premature ejaculation, but there is little agreement regarding the definition of this disorder or its etiology, diagnosis, and treatment options. Premature ejaculation is in fact classically considered psychogenic in nature. However, recent data have demonstrated that pro-static inflammation/infection has been found with high frequency in premature ejaculation, suggesting a role of prostatic pathologies in the patho-genesis of some cases of failure of ejaculatory control. Rarer disorders are emission and ejaculation failure and urine contamination of semen. The new use of diagnostic procedures and the availability of pharmacological aids place this topic in the mainframe of medical sexology.


Premature ejaculation delayed ejaculation retrograde ejaculation anorgasmia medical sexology 


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Copyright information

© Italian Society of Endocrinology (SIE) 2002

Authors and Affiliations

  1. 1.Course of Medical Sexology at the Department of Experimental Medicine of the University of L’AquilaL’AquilaItaly
  2. 2.Course of Psychology and Psychopathology of Sexual BehaviorDepartment of PsychologyItaly
  3. 3.Chairs of Clinical PathologyDepartment of Medical PhysiopathologyRomeItaly

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