Journal of Endocrinological Investigation

, Volume 23, Issue 8, pp 509–514

Circulating interleukin-6 significantly correlates to thyroid hormone in acute myocardial infarction but not in chronic heart failure

  • M. Nishino
  • T. Kimura
  • T. Kanda
  • N. Kotajima
  • A. Yoshida
  • A. Kuwabara
  • K. Tamama
  • Y. Fukumura
  • I. Kobayashi
Original Article

DOI: 10.1007/BF03343766

Cite this article as:
Nishino, M., Kimura, T., Kanda, T. et al. J Endocrinol Invest (2000) 23: 509. doi:10.1007/BF03343766

Abstract

To investigate relationships between thyroid states and the cardiac endocrine system, we analyzed thyrotropin (TSH), thyroid hormone, plasma levels of interleukin-6 (IL-6) and brain natriuretic peptide (BNP) in 50 patients with chronic heart failure (CHF), in 30 patients with heart failure from acute myocardial infarction (AMI), and in 15 controls. Plasma levels of IL-6 and BNP in both CHF and AMI were significantly elevated, while free triiodothyronine (FT3) was significantly decreased compared to controls. FT3/ free thyroxine (FT4) ratio was significantly decreased in CHF but not in AMI compared to controls. In CHF, diuretic treatment diminished circulating BNP but not IL-6, while diuretic treatment increased FT3/FT4 ratio. In AMI, FT3/ FT4 ratio was significantly decreased 72h compared to 12h after the onset of AMI, while BNP and IL-6 were significantly increased 72h compared to 12h after the onset of AMI. In both CHF and AMI, BNP significantly correlated with FT4. On the other hand, significant correlations between IL-6 and FT3, and between IL-6 and FT3/FT4 ratio were detected in AMI but not in CHF. This preliminary study suggests that IL-6, BNP and thyroid hormone reflect ventricular dysfunction in both acute and chronic heart failure, and that IL-6 significantly relates to circulating thyroid hormone in AMI but not in CHF.

Key-words

Interleukin-6 (IL-6) thyrotropin (TSH) free triiodothyronine (FT3free thyroxine (FT4chronic heart failure (CHF) acute myocardial infarction (AMI) brain natriuretic peptide (BNP) euthyroid sick syndrome (ESS) 

Copyright information

© Italian Society of Endocrinology (SIE) 2000

Authors and Affiliations

  • M. Nishino
    • 1
  • T. Kimura
    • 1
  • T. Kanda
    • 1
  • N. Kotajima
    • 1
  • A. Yoshida
    • 1
  • A. Kuwabara
    • 1
  • K. Tamama
    • 1
  • Y. Fukumura
    • 1
  • I. Kobayashi
    • 1
  1. 1.Department of Laboratory MedicineGunma University School of MedicineMaebashiJapan

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