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Journal of Endocrinological Investigation

, Volume 23, Issue 4, pp 228–230 | Cite as

Erythrocyte oxidant/antioxidant status of diabetic patients

  • S. Büyükkoçak
  • H. S. Öztürk
  • M. N. Tamer
  • M. Kaçmaz
  • M. Y. B. Çimen
  • I. DurakEmail author
Original Article

Abstract

Present study aims to establish erythrocyte oxidant/antioxidant status in diabetic patients with and without atherosclerotic complications. Fasting blood samples were obtained from 23 diabetic and 12 control subjects. Thirteen patients had no disease other than diabetes mellitus and 10 patients had also atherosclerosis in addition to diabetes mellitus. Erythrocyte antioxidant potential (AOP) and thiobarbituric acid reagent substances (TBARS) levels were measured in these patients and results were compared with those of controls, who were chosen among healthy subjects. Results suggest that although there is an oxidant stress in the erythrocytes of diabetics, this is not due to reduced erythrocyte antioxidant defence potential but, rather, increased free radical production possibly due to hyperglycemia.

Key-words

Antioxidant potential diabetes mellitus erythrocyte 

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Copyright information

© Italian Society of Endocrinology (SIE) 2000

Authors and Affiliations

  • S. Büyükkoçak
    • 1
  • H. S. Öztürk
    • 1
  • M. N. Tamer
    • 2
  • M. Kaçmaz
    • 1
  • M. Y. B. Çimen
    • 1
  • I. Durak
    • 1
    Email author
  1. 1.Department of Biochemistry and Medical FacultyAnkara UniversitySihhiye, AnkaraTurkey
  2. 2.Ankara UniversityTurkey

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