Aging Clinical and Experimental Research

, Volume 9, Issue 3, pp 185–192

Function of GH/IGF-I axis in aging: Multicenter study in 152 healthy elderly subjects with different degrees of physical activity

  • Italian Association for Research on Brain Aging (AIRIC) Multicenter Study Group
Article

Abstract

We evaluated somatotropic function in 142 healthy elderly subjects (54 men and 88 women), aged 60–90 years and in 10 non-professional, but regularly training elderly distance runners (7 men and 3 women), aged 60–71 years. In the healthy elderly, basal plasma growth hormone (GH) and insulin-like growth factor-I (IGF-I) median levels were 0.6 μg/L (25th and 75th centiles = 0.3, 1.3) and 100.5 μg/L (25th and 75th centiles = 63, 140), respectively. About 53% of the elderly had plasma IGF-I levels within the 3rd–97th centiles of young-adult subjects. Basal GH and IGF-I were not correlated with each other nor, with the degree of physical activity, evaluated by a self-administered questionnaire; however, basal GH showed a very weak positive correlation with age while IGF-I showed a highly significant negative correlation. The peak GH response to GHRH (1 μg/kg, iv), did not correlate with age, BMI and physical activity in 87/142 subjects investigated, but was highly correlated with basal GH levels. Correlation coefficients of plasma growth hormone binding protein (GHBP) with basal GH levels and peak GH levels following GHRH were r=-0.29 and r=-0.36, respectively, but statistical significance was not reached. In the “runners”, median values of both basal and GHRH-induced GH peak were higher than those recorded in the healthy elderly, but IGF-I levels were not significantly different and they too declined with age. These data suggest that: 1) plasma IGF-I rather than basal or stimulated GH is a better index for evaluating the effect of aging on the GH/IGF system; 2) while usual physical activity in itself does not influence somatotropic function, endurance training is related to higher basal GH levels, but fails to oppose the age-related decline of plasma IGF-I levels.

Key words

Aging growth hormone insulin-like growth factor-I multicenter study physical activity 

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References

  1. 1.
    Corpas E., Harman S.M., Blackman S.: Human growth hormone and human aging. Endocr. Rev. 14: 20–39, 1993b.PubMedGoogle Scholar
  2. 2.
    Ghigo E., Arvat E., Goffi S., Bellone J., Nicolosi M., Procopio M., Maccario M., Camanni F.: Neural control of growth hormone secretion in aged humans. In: Müller E.E., Cocchi D., Locatelli V. (Eds.), Growth Hormone and Somatomedins During Lifespan. Springer-Verlag, Berlin, 1993, pp. 275–287.CrossRefGoogle Scholar
  3. 3.
    Gil-Ad I., Gurewitz R., Marcovici O., Rosenfeld J., Laron Z.: Effects of aging on human plasma growth hormone response to clonidine. Mech. Ageing Dev. 27: 97–100, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    Hoffman A.R., Pyca G., Lieberman S.A., Ceda G.P., Marcus R.: The somatopause. In: Müller E.E., Cocchi D., Locatelli V. (Eds.), Growth Hormone and Somatomedins during Lifespan. Springer-Verlag, Berlin, 1993, pp. 265–274.CrossRefGoogle Scholar
  5. 5.
    Zadik Z., Chalew S.A., McCarter R.J., Meistas M., Kowarski A.A.: The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J. Clin. Endocrinol. Metab. 60: 513–516, 1985.PubMedCrossRefGoogle Scholar
  6. 6.
    Vermeulen A.: Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels. J. Clin. Endocrinol. Metab. 64: 884–888, 1987.PubMedCrossRefGoogle Scholar
  7. 7.
    Van Coevorden A., Mockel J., Laurent E.: Neuroendocrine rhythms and sleep in aging men. Am. J. Physiol. 260: 251–261, 1991.Google Scholar
  8. 8.
    Finkelstein J.W., Roffwarg H.P., Boyar R.M., Kream J., Hellman L.: Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J. Clin. Endocrinol. Metab. 35: 665–670, 1972.PubMedCrossRefGoogle Scholar
  9. 9.
    Iranmanesh A., Lizarralde G., Veldhuis J.D.: Age and relative adiposity are specific negative determinants of the frequency and amplitude of GH secretory burst and the half-life of endogenous GH in healthy men. J. Clin. Endocrinol. Metab. 73: 1081–1088, 1991.PubMedCrossRefGoogle Scholar
  10. 10.
    Dudl R.J., Ensinck J.W., Palmer H.E., William R.H.: Effect of age on growth hormone secretion in man. J. Clin. Endocrinol. Metab. 37: 11–16, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Ghigo E., Goffi S., Nicolosi M., Arvat E., Bellone J., Procopio M., Valente F., Mazza E., Ghigo M.C., Camanni F.: Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J. Clin. Endocrinol. Metab. 71: 1481–1485, 1990.PubMedCrossRefGoogle Scholar
  12. 12.
    Muggeo M., Fedele D., Molinari M., Crepaldi G.: Human growth hormone and cortisol response to insulin stimulation in aging. J. Gerontol. 30: 546–551, 1975.PubMedCrossRefGoogle Scholar
  13. 13.
    Rudman D., Kutner M.H., Rogers M., Lubin M.F., Fleming G.A., Bain R.P.: Impaired growth hormone secretion in the adult population. J. Clin. Invest. 67: 1361–1369, 1981.PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Florini J.R., Roberts S.B.: Effect of age on blood levels of somatomedin-like growth factor. J. Gerontol. 35: 23–30, 1979.CrossRefGoogle Scholar
  15. 15.
    Florini J.R., Harned J., Richman R., Weiss J.: Effect of rat age on serum levels of growth hormone and somatomedins. Mech. Ageing Dev. 15: 165–176, 1981.PubMedCrossRefGoogle Scholar
  16. 16.
    Sonntag W.E., Steger R.W., Forman L.J., Meites J.: Decreased pulsatile release of growth hormone in old male rats. Endocrinology 107: 1875–1879, 1980.PubMedCrossRefGoogle Scholar
  17. 17.
    Breese C.R., Ingram R.L., Sonnag W.E.: Influence of age and long-term dietary restriction on plasma insulin-like growth factor-I (IGF-I), IGF-I gene expression, and IGF-I binding proteins. J. Gerontol. 46: B180–B187, 1991.PubMedCrossRefGoogle Scholar
  18. 18.
    Kahler L.W., Brief S., Westly H., Novakofski J., Bechtel P., Simon J., Walker E.: Loss of enhanced nocturnal growth hormone secretion in aging rhesus monkeys. Endocrinology 119: 1281–1284, 1986.CrossRefGoogle Scholar
  19. 19.
    Clemmons D.R., Van Wyk J.J.: Factors controlling blood concentration of somatomedin-C. J. Clin. Endocrinol. Metab. 13: 113–120, 1984.Google Scholar
  20. 20.
    Rudman D., Axel G.F., Nagraj H.S., Gergans G.A., Lalitha P.Y., Goldberg A.F., Schlenker R.A., Cohn L., Rudman I.W., Mattson D.E.: Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323: 1–6, 1990.PubMedCrossRefGoogle Scholar
  21. 21.
    Corpas E., Harman M., Pineyro M.A., Robertson R., Blackman R.: Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J. Clin. Endocrinol. Metab. 75: 530–535, 1992.PubMedGoogle Scholar
  22. 22.
    Corpas E., Harman M., Pineyro M.A., Robertson R., Blackman R.: Continuous subcutaneous infusions of GHRH 1-44 for 14 days increase GH and IGF-I levels in old men. J. Clin. Endocrinol. Metab. 76: 134–138, 1993a.PubMedGoogle Scholar
  23. 23.
    Thompson J.L., Butterfield G.E., Marcus R.: The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J. Clin. Endocrinol. Metab. 80: 1845–1852, 1995.PubMedGoogle Scholar
  24. 24.
    Lamberts S.W., Vall N.K., Binnerts A.: The use of growth hormone in adults: a changing scene. Clin. Endocrinol. (Oxf.) 37: 111–115, 1992.CrossRefGoogle Scholar
  25. 25.
    Daughaday W.H., Mariz I.K., Blethen S.L.: Inhibition of access of bound somatomedin to membrane receptor and immunoglobulin sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum. J. Clin. Endocrinol. Metab. 19: 781–788, 1980.CrossRefGoogle Scholar
  26. 26.
    Baumann G., Shaw M.A., Amburn K.: Regulation of plasma growth hormone-binding proteins in health and disease. Metabolism 38: 683–689, 1989.PubMedCrossRefGoogle Scholar
  27. 27.
    Aaronson N.K., Acquadro C., Alonso J., Apolone G., Bucquet D., Bullinger M.: International quality of life assessment (IQOLA) project. Quality of Life Research 1: 349–351, 1992.PubMedCrossRefGoogle Scholar
  28. 28.
    Ware J.J.: SF-36 Health Survey. Manual and Interpretation guide. The Health Institute, New England Medical Center. Boston, Massachusetts, 1993.Google Scholar
  29. 29.
    McHorney C.A., Ware J.E., Lu J.F.R., Sherbourne C.D.: The MOS 36-item short-form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med. Care 32: 40–66, 1994.PubMedCrossRefGoogle Scholar
  30. 30.
    Ghigo E., Aimaretti G., Gianotti L., Bellone J., Arvat E., Camanni F.: New approach to the diagnosis of growth hormone deficiency in adults. Eur. J. Endocrinol. 134: 352–356, 1996.PubMedCrossRefGoogle Scholar
  31. 31.
    Pohelman E.T., Copeland K.C.: Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J. Clin. Endocrinol. Metab. 71: 1468–1473, 1990.CrossRefGoogle Scholar
  32. 32.
    Craig B.W.R., Brown J.E.: Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech. Ageing Dev. 49: 159–169, 1989.PubMedCrossRefGoogle Scholar
  33. 33.
    Pyka G., Wiswell R.A., Marcus R.: Age-dependent effect of resistance exercise on growth hormone secretion in people. J. Clin. Endocrinol. Metab. 75: 404–407, 1992.PubMedGoogle Scholar
  34. 34.
    Blackman M.R.: Pituitary hormones and aging. Endocrinol. Metab. Clin. 16: 981–994, 1987.Google Scholar
  35. 35.
    Felicetta J.V.: The thyroid and aging. In: Sowers J.R., Felicetta J.V. (Eds.), Endocrinology of aging. Raven Press, New York, 1988, pp. 15–41.Google Scholar
  36. 36.
    Mariotti S., Barbesino G., Caturegli P., Bartalena L., Sansoni P., Fagnoni F., Monti D., Fagiolo U., Franceschi C., Pinchera A.: Complex alteration of thyroid function in healthy centenarians. J. Clin. Endocrinol. Metab. 77: 1130–1134, 1993.PubMedGoogle Scholar
  37. 37.
    Rodriguez-Arnao J., Miell J.P., Ross R.J.M.: Influence of thyroid hormones on the GH-IGF-I axis. Trends in Endocrinol. Metab. 4: 169–173, 1993.CrossRefGoogle Scholar
  38. 38.
    Jorgensen J.O.L., Meller J., Laursen T., Orskov H., Christiansen J.S., Weeke J.: Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotropin levels: studies in GH-deficient adults. Clin. Endocrinol. (Oxf.) 41: 609–614, 1994.CrossRefGoogle Scholar
  39. 39.
    Baumann G., Shaw M.A., Amburn K.: Circulating growth hormone binding proteins. J. Endocrinol. Invest. 17: 67–81, 1994.PubMedGoogle Scholar
  40. 40.
    Maheshwari H., Sharma L., Baumann G.: Decline of plasma growth hormone binding protein in old age. J. Clin. Endocrinol. Metab. 81: 995–997, 1996.PubMedGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 1997

Authors and Affiliations

  • Italian Association for Research on Brain Aging (AIRIC) Multicenter Study Group
    • 1
  1. 1.Department of Medical PharmacologyUniversity of MilanoMilanoItaly

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