Aging Clinical and Experimental Research

, Volume 10, Issue 3, pp 205–213

Heritable and nutritional influences on bone mineral mass

  • S. Ferrari
  • R. Rizzoli
  • J-P. Bonjour
Review Article

DOI: 10.1007/BF03339654

Cite this article as:
Ferrari, S., Rizzoli, R. & Bonjour, JP. Aging Clin Exp Res (1998) 10: 205. doi:10.1007/BF03339654

Abstract

Osteoporosis is the net result of the maximal amount of bone mineral mass achieved by the end of pubertal growth (peak bone mass) minus post-menopausal and elderly bone losses. Peak bone mineral mass is determined from early childhood by both heritable and environmental factors. Recent developments in the molecular epidemiology of osteoporosis have shown the interest, but also the limitations, of specific molecular markers, such as the vitamin D receptor gene polymorphisms Bsm 1 and Fok 1, to explain bone mineral density differences across the population. Importantly, however, interactions between VDR gene polymorphisms and environmental factors, particularly dietary calcium, have provided new insights into the complex determination of bone mineral mass.

Key words

Calcium intake heredity osteoporosis peak bone mass polymorphism vitamin D receptor 

Copyright information

© Springer Internal Publishing Switzerland 1998

Authors and Affiliations

  • S. Ferrari
    • 1
    • 2
  • R. Rizzoli
    • 1
    • 2
  • J-P. Bonjour
    • 1
    • 2
  1. 1.Division of Bone DiseasesWHO Collaborating Center for Osteoporosis and Bone DiseasesGenevaSwitzerland
  2. 2.Department of Internal MedicineUniversity HospitalGenevaSwitzerland
  3. 3.Division of Bone and Mineral Metabolism, Beth Israel Deaconess Medical CenterHarvard Institute of MedicineBostonUSA

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