Aging Clinical and Experimental Research

, Volume 10, Issue 2, pp 137–140

Inverse association of serum cholesterol with plasma insulin in the elderly. Cross-sectional and prospective analyses

  • O. Lindberg
  • R. S. Tilvis
  • T. E. Strandberg
  • A. Lehtonen
  • C. Ehnholm
  • J. Tuomilehto
Original Article

Abstract

Cross-sectional studies have suggested that high plasma insulin is associated with relatively low levels of low density lipoprotein (LDL)-cholesterol. The present study was aimed at re-testing this association in a 70-year-old age cohort (N=1023), and testing whether it could be caused by excessive mortality of hyperinsulinemic subjects with high LDL-cholesterol. A reverse U-shaped association between LDL-cholesterol and fasting plasma insulin was confirmed. LDL-cholesterol, HDL-cholesterol and total cholesterol were lowest in the highest insulin quarter. These associations remained after adjustment for diabetes, obesity and general health status. The combination of high LDL-cholesterol (>4.25 mmol/L, 75th percentile) and high insulin (>10 IU/L, 50th percentile) was not associated with excess 5-year mortality in this age cohort. Nor was it associated with excess mortality in four other elderly age cohorts (N=1188), in which similar associations of cholesterol and insulin have been demonstrated. Thus, the inverse association of LDL-cholesterol with fasting insulin in the elderly is not caused by selective over mortality.

Key words

Cholesterol elderly insulin lipids mortality risk factors 

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Copyright information

© Springer Internal Publishing Switzerland 1998

Authors and Affiliations

  • O. Lindberg
    • 1
  • R. S. Tilvis
    • 1
  • T. E. Strandberg
    • 1
  • A. Lehtonen
    • 2
  • C. Ehnholm
    • 3
  • J. Tuomilehto
    • 3
  1. 1.Division of Geriatrics, Department of MedicineUniversity of HelsinkiHelsinkiFinland
  2. 2.Turku City HospitalTurkuFinland
  3. 3.National Public Health InstituteHelsinkiFinland

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