Aging Clinical and Experimental Research

, Volume 23, Issue 1, pp 17–21

JAK2V617F mutation is common in old patients with polycythemia vera and essential thrombocythemia

  • Maria Luigia Randi
  • Elisabetta Ruzzon
  • Fabiana Tezza
  • Margherita Scapin
  • Elena Duner
  • Raffaella Scandellari
  • Fabrizio Fabris
Original Article

DOI: 10.1007/BF03324948

Cite this article as:
Randi, M.L., Ruzzon, E., Tezza, F. et al. Aging Clin Exp Res (2011) 23: 17. doi:10.1007/BF03324948

Abstract

Background: JAK2V617F mutation occurs in 90% of polycythemia vera (PV) and in 50% of essential thrombocythemia (ET) patients. Materials and methods: 253 consecutive patients affected by myeloproliferative disorders (MPD, 121 PV, 132 ET) were evaluated and stratified in 4 age groups: 18–39, 40–59, 60–75 and over 75 years (>75). The JAK2V617F mutation was searched and its allele burden was evaluated. Results: The percentage of mutated patients increased progressively with age mainly in patients >75 (p=0.0015 vs 18–39, p=0.0021 vs 40–59 and p=0.012 vs 60–75). We also found a progressive increase in allele burden with age (R2=0.042). Thrombotic events were more common in patients carrying the mutation in comparison with wild type (WT) (p=0.006, coefficient risk 1.94). No differences in the percentage of patients carrying the JAK2V617F mutation were found, in spite of different follow-up durations (<5 yrs, 5–10 yrs, 10–15 yrs, >15 yrs). The JAK2V617F allele burden was similar in patients with (57±31%) and without (45±26%) long-term hydroxyurea treatment. Conclusions: JAK2V617F mutation is more common in old than in young patients with MPD. Older patients have an higher allele burden.

Essential thrombocythemia JAK2V617F polycythemia vera 

Copyright information

© Springer Internal Publishing Switzerland 2011

Authors and Affiliations

  • Maria Luigia Randi
    • 1
  • Elisabetta Ruzzon
    • 1
  • Fabiana Tezza
    • 1
  • Margherita Scapin
    • 1
  • Elena Duner
    • 1
  • Raffaella Scandellari
    • 1
  • Fabrizio Fabris
    • 1
  1. 1.Internal Medicine CLOPD, Department of Medical and Surgical SciencesUniversity of Padova Medical SchoolPadovaItaly

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