Aging Clinical and Experimental Research

, Volume 18, Issue 6, pp 493–496 | Cite as

Radioisotopic assessment of gastric emptying of solids in elderly subjects

  • Alflo Brogna
  • Massimiliano Loreno
  • Filippo Catalano
  • Anna Maria Bucceri
  • Mariano Malaguarnera
  • Liboria Agata Muratore
  • Salvatore Travali
Original Article


Backgrounds and aims: Few studies in literature have investigated the gastric emptying of solids in elderly subjects. We assessed the differences between young and elderly subjects in the gastric emptying rate of solids by a radioisotopic method. Methods: Two groups of 15 elderly male subjects (mean age 68.20 years and 77.26 years, respectively) and a group of young male subjects (mean age 30.23 years) underwent a radioisotopic study of gastric emptying after eating a radiolabeled solid meal. Half-time of gastric emptying (T½) and emptying index (EI), i.e. rate of gastric emptying at 120 min, were measured with two opposing detectors connected to a computerized rate-meter. Results are expressed as means ± SD. Results: Significantly different values were obtained in the two groups both at T½ (183±88 and 195±75, respectively) and EI (0A0±0.3 and 0.36±0.4), compared with young subjects (T½=53±23; EI=1.10±0.3) (p<0.0001). Conclusions: Gastric emptying of solids is significantly delayed in elderly men; this variable must be taken into account when studies on gastric emptying rates are performed.


gastric emptying radioisotope 


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  1. 1.
    Malagelada JR. Physiologic basis and clinical significance of gastric emptying disorders. Dig Dis Sci 1979; 24: 657–61.PubMedCrossRefGoogle Scholar
  2. 2.
    Moore JG, Tweedy C, Christian PE, Datz FL. Effect of age on gastric emptying of liquid-solid meal in man. Dig Dis Sci 1983; 4: 340–4.CrossRefGoogle Scholar
  3. 3.
    Horowitz M, Maddern GJ, Chatterton BE, Collins PJ, Harding PE, Shearman DJ. Changes in gastric emptying rates with age. Clin Sci 1984; 67: 213–8.PubMedGoogle Scholar
  4. 4.
    Gainsborough N, Maskrey VL, Nelson ML, et al. The association of age with gastric emptying. Age Ageing 1993; 22: 37–40.PubMedCrossRefGoogle Scholar
  5. 5.
    Shimamoto C, Hirata I, Hiraike Y, Takeuchi N, Nomura T, Katsu K. Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test. Gerontology 2002; 48: 381–6.PubMedCrossRefGoogle Scholar
  6. 6.
    Goldschmiedt M, Barnett CC, Schwartz BE, Karnes WE, Redfern JS, Feldman M. Effect of age on gastric acid secretion and serum gastric concentrations in healthy men and women. Gastroenterology 1991; 101: 977–90.PubMedGoogle Scholar
  7. 7.
    Feldman M, Cryer B, McArthur KE, Huet BA, Lee E. Effects of aging and gastritis on gastric add and pepsin secretion in humans: A prospective study. Gastroenterology 1996; 110: 1043–52.PubMedCrossRefGoogle Scholar
  8. 8.
    Smits GJ, Lefebvre RA. Influence of aging on gastric emptying of liquids, small intestine transit and fecal output in rats. Exp Gerontol 1996; 31: 589–96.PubMedCrossRefGoogle Scholar
  9. 9.
    Varga F. Transit time changes with age in the gastrointestinal tract of the rat. Digestion 1976; 14: 319–24.PubMedCrossRefGoogle Scholar
  10. 10.
    Brogna A, Catalano F, Mangiameli A, et al. Simultaneous measurement of gastric emptying of digestible and indigestible solids in healthy humans. Ital J Gastrenterol 1992; 24: 188–91.Google Scholar
  11. 11.
    O’Donovan D, Hausken T, Lei Y, et al. Effect of aging on transpyloric flow, gastric emptying, and intragastric distribution in healthy humans — impact on glycemia. Dig Dis Sci 2005; 50: 671–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Madsen JL. Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing 2004; 33: 154–9.Google Scholar
  13. 13.
    Datz FL, Christian PE, Moore J. Gender-related differences in gastric emptying. J Nucl Med 1987; 28: 1204–7.PubMedGoogle Scholar
  14. 14.
    Madsen JL. Effect of gender, age, and body mass index on gastrointestinal transit time. Dig Dis Sci 1992; 37: 1548–53.PubMedCrossRefGoogle Scholar
  15. 15.
    Brogna A, Ferrara R, Bucceri AM, Catalano F, Natoli G, Leocata V. Gastric emptying rates of solid food in relation to body mass index: an ultrasonographic and scintigraphic study. Eur J Radiol 1988; 27: 258–63.CrossRefGoogle Scholar
  16. 16.
    Feldman M, Smith HJ, Simon TR. Gastric emptying of solid radiopaque markers: Studies in healthy subjects and diabetic patients. Gastroenterology 1984; 87; 895–902.PubMedGoogle Scholar
  17. 17.
    Loreno M, Bucceri AM, Catalano F, Blasi A, Brogna A. Gastric clearance of radiopaque markers in the evaluation of gastric emptying rate. Scand J Gastroenterol 2004; 39: 1215–8.PubMedCrossRefGoogle Scholar
  18. 18.
    George JD. New clinical method for measuring the role of gastric emptying: The double-sampling test meal. Gut 1968; 9: 237–42.PubMedCrossRefGoogle Scholar
  19. 19.
    Holt S, McDicken WN, Anderson T, et al. Dynamic imaging of the stomach by real-time ultrasound - a method for the study of gastric motility. Gut 1980; 21; 597–601.PubMedCrossRefGoogle Scholar
  20. 20.
    You CH, Lee KY, Chey WY, et al. Electrogastrographic study of patients with unexplained nausea, bloating and vomiting. Gastroenterology 1980; 9: 311–4.Google Scholar
  21. 21.
    Marciani L, Young P, Wright J, et al. Antral motility measurements by magnetic resonance imaging. Neurogastroenterol Motil 2001; 13: 511–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Perri F, Clemente R, Festa V, Quitadamo M, Niro G, Andriulli A. 13C-octanoic acid breath test: a reliable tool for measuring gastric emptying. Ital J Gastroenterol Hepatol 1998; 30: 211–7.PubMedGoogle Scholar
  23. 23.
    Jobin G. Jian R. Isotope studies in gastric emptying. Dig Dis Sci 1982; 27: 571–2.CrossRefGoogle Scholar
  24. 24.
    Clarke BF, Ewing DJ, Campbell IW. Diabetic autonomie neuropathy. Diabetologia 1979; 17: 195–212.PubMedCrossRefGoogle Scholar
  25. 25.
    Elashoff JD. Reedy TJ. Meyer JH. Analysis of gastric emptying data. Gastroenterology 1982; 83: 1306–12.Google Scholar
  26. 26.
    Grimes DS. Goddard J. Gastric emptying of a whole-meal and white bread. Gut 1977; 18: 72–9.Google Scholar
  27. 27.
    Brogna A, Ferrara R, Bucceri AM, Lanteri E, Catalano F. Influence of aging on gastrointestinal transit time: an ultrasonographic and radiologie study. Invest Radiol 1999; 34: 357–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Jones KL, Horowitz M, Carney BI, Sun WM, Chatterton BE. Effects of cisapride on gastric emptying of oil and aqueous meal components, hunger, and fullness. Gut 1996; 38: 310–5.PubMedCrossRefGoogle Scholar
  29. 29.
    Hveem K, Jones KL, Chatterton BE, Horowitz M. Scintigraphic measurement of gastric emptying and ultrasonographic assessment of antral area: relation to appetite. Gut 1996; 38: 816–21.PubMedCrossRefGoogle Scholar
  30. 30.
    Madsen JL. Graff J. Effects of ageing on gastrointestinal motor function. Age Ageing. 2004; 33: 154–9.Google Scholar
  31. 31.
    Kao CH, Lai TL, Wang SJ, Chen GH, Yeh SH. Influence of age on gastric emptying in healthy Chinese. Clin Nucl Med 1994; 19: 401–4.PubMedCrossRefGoogle Scholar
  32. 32.
    Graff J, Brinch K, Madsen JL. Gastrointestinal mean transit times in young and middle-aged healthy subjects. Clin Physiol. 2001; 21: 253–9.PubMedCrossRefGoogle Scholar
  33. 33.
    Clarkston WK, Pantano MM, Morley JE, Horoitz M, Littlefield JM, Burton FR. Evidence for anorexia of aging: Gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol 1997; 272: 243–8.Google Scholar
  34. 34.
    Chapman IM, Macintosh CG, Morley JE, et al. The anorexia of ageing. Biogerontology 2002; 3: 67–71.PubMedCrossRefGoogle Scholar
  35. 35.
    Morley JE. Anorexia and weight loss in older persons. J Gerontol A Biol Sci Med Sci 2003; 58: 131–7.PubMedCrossRefGoogle Scholar
  36. 36.
    Morley JE. Silver AJ. Anorexia in the elderly. Neurobiol Aging 1988; 9: 9–16.CrossRefGoogle Scholar
  37. 37.
    Baron JH. Studies of basal and peak acid output with an augmented histamine meal. Gut 1963; 4: 136–44.PubMedCrossRefGoogle Scholar
  38. 38.
    Husebye E, Engedal K. The patterns of motility are maintained in the human small intestine throughout the process of aging. Scand J Gastroenterol 1992; 27: 397–404.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 2006

Authors and Affiliations

  • Alflo Brogna
    • 1
  • Massimiliano Loreno
    • 1
  • Filippo Catalano
    • 2
  • Anna Maria Bucceri
    • 1
  • Mariano Malaguarnera
    • 3
  • Liboria Agata Muratore
    • 1
  • Salvatore Travali
    • 4
  1. 1.Department of Internal Medicine and Internal SpecialitiesInstitute of Internal Medicine and GeriatricsOspedale Cannizzaro
  2. 2.Gastroenterology and Endoscopy UnitInstitute of Internal Medicine and GeriatricsOspedale Cannizzaro
  3. 3.Department of Senescent, Urological and Neurological SciencesInstitute of Internal Medicine and GeriatricsOspedale Cannizzaro
  4. 4.Department of Biomedical Science, Section of Clinical Pathology and Molecular OncologyUniversity of CataniaCataniaItaly

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