Aging Clinical and Experimental Research

, Volume 16, Issue 5, pp 337–341 | Cite as

Peritoneal macrophages function modulation by L-carnitine in aging rats

  • V. Nimet Izgüt-UysalEmail author
  • Arzu Agaç
  • Ihsan Karadogan
  • Narin Derin
Original Article


Background and aims: The aging process is associated with a progressive decline in physiological functions involving immune response in most species. The aim of the present study was to determine the effect of L-carnitine on impaired macrophages function in aged rats. Methods: Superoxide anion production, chemotaxis and phagocytic activity were studied in peritoneal macrophages obtained from young (2 months old) and aged (24 months old) rats. L-carnitine (50 mg/kg bw) or control vehicle was orally gavaged into young and aged rats for 30 consecutive days. Results: The peritoneal macrophages of the aged rats exhibited an increase in superoxide anion generation and a decline in chemotaxis and phagocytic index by comparison with the young rats. Superoxide anion production in aged rats was significantly reduced by L-carnitine treatment, as accompanied by a significant enhancement of chemotactic activity, which was restored to control levels observed in young rats. The age-related reduction in phagocytic index was only slightly, but not significantly, restored by L-carnitine administration, however. Conclusion: The findings suggest that L-carnitine administration may be useful in reversing some age-related changes.

Key Words

Aging macrophages phagocytosis superoxide anion 


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Copyright information

© Springer Internal Publishing Switzerland 2004

Authors and Affiliations

  • V. Nimet Izgüt-Uysal
    • 1
    Email author
  • Arzu Agaç
    • 1
  • Ihsan Karadogan
    • 2
  • Narin Derin
    • 1
  1. 1.Department of Physiology, Faculty of MedicineAkdeniz UniversityAntalyaTurkey
  2. 2.Department of Hematology, Faculty of MedicineAkdeniz UniversityAntalyaTurkey

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