Peritoneal macrophages function modulation by L-carnitine in aging rats
Background and aims: The aging process is associated with a progressive decline in physiological functions involving immune response in most species. The aim of the present study was to determine the effect of L-carnitine on impaired macrophages function in aged rats. Methods: Superoxide anion production, chemotaxis and phagocytic activity were studied in peritoneal macrophages obtained from young (2 months old) and aged (24 months old) rats. L-carnitine (50 mg/kg bw) or control vehicle was orally gavaged into young and aged rats for 30 consecutive days. Results: The peritoneal macrophages of the aged rats exhibited an increase in superoxide anion generation and a decline in chemotaxis and phagocytic index by comparison with the young rats. Superoxide anion production in aged rats was significantly reduced by L-carnitine treatment, as accompanied by a significant enhancement of chemotactic activity, which was restored to control levels observed in young rats. The age-related reduction in phagocytic index was only slightly, but not significantly, restored by L-carnitine administration, however. Conclusion: The findings suggest that L-carnitine administration may be useful in reversing some age-related changes.
Key WordsAging macrophages phagocytosis superoxide anion
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- 6.Athanassakis I, Dionyssopoulou E, Papanikou S, Evangeliou A, Vassiliadis S. Early events of the exogenously provided L-carnitine in murine macrophages, T- and B-lymphocytes: modulation of prostaglandin E1 and E2 production in response to arachidonic acid. J Nutr Biochem 2003; 14: 350–7.PubMedCrossRefGoogle Scholar
- 26.Manna SK, Samanta S, Samanta AK. Hamycin inhibits IL-8-in-duced biologic response by modulating its receptor in human polymorphonuclear neutrophils. J Immunol 1997; 15: 5042–52.Google Scholar