Aging Clinical and Experimental Research

, Volume 16, Issue 2, pp 104–112

The aging factor in health and disease: The promise of basic research on aging

  • Robert N. Butler
  • Huber R. Warner
  • T. Franklin Williams
Special Report


Age-related disease aging health care costs healthy aging life expectancy morbidity senescence 


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  1. 1.
    Finch CE. 1990. Longevity, senescence and the genome. Chicago, Ill: University of Chicago Press, 1990.Google Scholar
  2. 2.
    Schneider EL. Aging in the third millennium. Science 1999; 283: 796–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Brody JA, Schneider EL. Diseases and disorders of aging: an hypothesis. J Chron Dis 1986; 39: 871–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Hardy J, Gwinn-Hardy K. Genetic classification of primary neurodegenerative disease. Science 1998; 282: 1075–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Warner HR, Hodes RJ, Pocinki K. What does cell death have to do with aging? J Am Geriatr Soc 1997; 45: 1140–6.PubMedGoogle Scholar
  6. 6.
    Goffeau A, Barrell BG, Bussey H, et al. Life with 6000 genes. Science 1996; 274: 563–7.CrossRefGoogle Scholar
  7. 7.
    Blattner FR, Plunkett G, Bloch CA, et al. The complete sequence of Escherichia coli K-12. Science 1997; 277: 1453–74.PubMedCrossRefGoogle Scholar
  8. 8.
    The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: A platform for investigating biology. Science 1998; 282: 2012–8.Google Scholar
  9. 9.
    Rose MR. Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 1984; 38: 1004–10.CrossRefGoogle Scholar
  10. 10.
    Herskind AM, McGue M, Holm NV, Sorensen TI, Harvald B, Vaupel JW. The heritability of human longevity: a population-based study of 2,872 Danish twin pairs born 1870–1900. Hum Genet 1996; 97: 319–23.PubMedCrossRefGoogle Scholar
  11. 11.
    Rudolph KL, Chang L, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999; 96: 701–12.PubMedCrossRefGoogle Scholar
  12. 12.
    Sprott RL, Austad SN. Animal models for aging research. In Schneider EL, Rowe JW, Eds. Handbook of the biology of aging, 4th ed. San Diego: Academic Press, 1996: 3–23.Google Scholar
  13. 13.
    Battey J, Jordan E, Cox D, Dove W. An action plan for mouse genomics. Nature Genetics 1999; 21: 73–5.PubMedCrossRefGoogle Scholar
  14. 14.
    McClearn GE. Heterogeneous reference populations in animal research on aging. ILAR J 1997; 38: 119–23.PubMedCrossRefGoogle Scholar
  15. 15.
    Harrison DE, Broderick TH. Selection for maximum longevity in mice. Exp Gerontol 1997; 32: 65–78.PubMedCrossRefGoogle Scholar
  16. 16.
    Miller RA, Chrisp C, Jackson AU, Burke D. Marker loci associated with lifespan in genetically heterogeneous mice. J Gerontol 1998; 53A: M257–63.CrossRefGoogle Scholar
  17. 17.
    Couzin K. Low-calorie diets may slow monkey’s aging. Science 1998; 282: 1018.PubMedCrossRefGoogle Scholar
  18. 18.
    Holmes D, Austad S. Birds as animal models for comparative biology of aging: A prospectus. J Gerontol 1995; 50A: B59–66.CrossRefGoogle Scholar
  19. 19.
    Morris J, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996; 382: 536–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277: 942–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Lin Y-J, Seroude L, Benzer S. Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 1998; 282: 943–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpres-sion of human SOD1 in motor neurons. Nature Genetics 1998; 19: 171–4.PubMedCrossRefGoogle Scholar
  23. 23.
    Williams MD, Van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J Biol Chem 1998; 273: 28510–5.PubMedCrossRefGoogle Scholar
  24. 24.
    Morgan WM, Richardson A, Sharp ZD, Walter CA. Application of exogenously regulatable promoter systems to transgenic models for the study of aging. J Gerontol 1999; 54A: B30–40.Google Scholar
  25. 25.
    Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice. Science 1996; 274: 99–102.PubMedCrossRefGoogle Scholar
  26. 26.
    Lander ES. Array of hope. Nature Genetics 1999; 21: 3–4.PubMedCrossRefGoogle Scholar
  27. 27.
    Chakravarti A. Population genetics-Making sense out of sequence. Nature Genetics 1999; 21: 56–60.PubMedCrossRefGoogle Scholar
  28. 28.
    Ye L, Miki T, Nakura J, et al. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet 1997; 68: 494–9.PubMedCrossRefGoogle Scholar
  29. 29.
    Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363–7.PubMedCrossRefGoogle Scholar
  30. 30.
    Campisi J. Aging and cancer: the double-edged sword of replicative senescence. J Am Geriatr Soc 1997; 45: 482–8.PubMedGoogle Scholar
  31. 31.
    Bodnar AG, Ouellete M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349–52.PubMedCrossRefGoogle Scholar
  32. 32.
    Jiang XR, Jimenez G, Chang E, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genetics 1999; 21: 111–4.PubMedCrossRefGoogle Scholar
  33. 33.
    Gearhart J. New potential for human embryonic stem cells. Science 1998; 282: 1061–2.PubMedCrossRefGoogle Scholar
  34. 34.
    Lamberts SWJ, van den Beld AW, van der Lely AJ. The endocrinology of aging. Science 1997; 278: 419–24.PubMedCrossRefGoogle Scholar
  35. 35.
    Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323: 1–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 2004

Authors and Affiliations

  • Robert N. Butler
    • 1
  • Huber R. Warner
    • 2
  • T. Franklin Williams
    • 3
  1. 1.International Longevity Center-USA, Alliance for Health & the Future, and Department of GeriatricsMount Sinai Medical CenterNew York
  2. 2.Biology of Aging ProgramNational Institute on AgingBethesda
  3. 3.Monroe Community HospitalUniversity of RochesterRochesterUSA

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